dynemicin O
National Institutes of Health
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Synthetic study of biologically important nitrogen-containing natural products and development of new methodologies and design of…
Dynemicin A (1) is aìpotentautitumor antibiotic with unique molecular ìstructure and fascinating mode of action.’ It has been…
Two series of hybrids of a dynemicin A model and DNA minor groove binding lexitropsins were synthesized and their cytotoxic…
New dynemicin A mimics with methyl group 2a and 2b were synthesized, and acid-induced hydrolyzed to see an electronic effect of…
We found here that dynemicin A effectively breaks DNA strands under alkaline pH condition. Binding of dynemicin A to double…
Molecular dynamics (MD) simulations to model possible reaction pathways of the dynemicin‐A‐DNA cleavage mechanism were performed…
We report here that the DNA strand scission by dynemicin A is not only sequence-specific but also conformation-specific. The salt…
Dynemicin A, which is a hybrid antitumor antibiotic containing anthraquinone and enediyne cores, effectively breaks DNA strands…