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divicine

Known as: 2,5-diamino-4,5-diketopyrimidine 
National Institutes of Health

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1 relation

Broader (1)

Pyrimidinones

Papers overview

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2001
2001
Favism: effect of divicine on rat erythrocyte sulfhydryl status, hexose monophosphate shunt activity, morphology, and membrane skeletal proteins.
Favism is an acute anemic crisis that can occur in susceptible individuals who ingest fava beans. The fava bean pyrimidine… 
1992
1992
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism.
Highly Cited
1989
Highly Cited
1989
Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide-induced release of tumor necrosis factor.
Secretion of TNF from mouse peritoneal macrophages exposed to LPS in vitro was enhanced in the presence of H2O2 or sodium… 
1987
1987
Toxicity of certain products of lipid peroxidation to the human malaria parasite Plasmodium falciparum.
Highly Cited
1984
Highly Cited
1984
Activity of divicine in Plasmodium vinckei‐infected mice has implications for treatment of favism and epidemiology of G‐6‐PD deficiency
Summary. Intravenous injection of divicine into mice infected with Plasmodium vinckei rapidly killed the parasites and caused… 
1984
1984
Mechanism of Action of Divicine in a Cell-free System and in Glucose-6-phosphate Dehydrogenase-deficient Red Cells
Favism is an acute hemolysis occurring in glucose-6-phosphate dehydrogenase (G6PD)-deficient (Mediterranean variant) individuals… 
1983
1983
Effect of factors of favism on the protein and lipid components of rat erythrocyte membrane.
1983
1983
A novel method for quantitation of favism-inducing agents in legumes.
Highly Cited
1982
Highly Cited
1982
The chemistry of favism-inducing compounds. The properties of isouramil and divicine and their reaction with glutathione.
Isouramil and divicine are pyrimidine aglycones of two glucosides found in broad beans. They have been shown to be strong… 
1981
1981
Effect of divicine and isouramil on red cell metabolism in normal and G6PD-deficient (Mediterranean variant) subjects. Possible role in the genesis of favism.
Fava beans contain high amounts (up to 6.7 g/100 g dry weight) vicine and convicine. Their active aglycones divicine and… 
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