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diosgenone

 
National Institutes of Health

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Spiro CompoundsTriterpenes

Papers overview

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2014
2014
Partial characterization of Plasmodium falciparum trophozoite proteome under treatment with quinine, mefloquine and the natural antiplasmodial diosgenone.
INTRODUCTION Despite efforts to control malaria, around 10% of the world population is at risk of acquiring this disease… Expand
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Review
2013
Review
2013
Diosgenone Synthesis, Anti-Malarial Activity and QSAR of Analogues of This Natural Product
Solanum nudum Dunal steroids have been reported as being antimalarial compounds; however, their concentration in plants is low… Expand
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2012
2012
Identification and functional analysis of cytochrome P450 complement in Streptomyces virginiae IBL14
BackgroundAs well known, both natural and synthetic steroidal compounds are powerful endocrine disrupting compounds (EDCs) which… Expand
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2009
2009
Characterization of P450 FcpC, the Enzyme Responsible for Bioconversion of Diosgenone to Isonuatigenone in Streptomyces virginiae IBL-14
ABSTRACT A new cytochrome P450 monooxygenase, FcpC, from Streptomyces virginiae IBL-14 has been identified. This enzyme is found… Expand
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2007
2007
Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14
An actinomycete strain IBL-14 isolated from soil by utilizing diosgenin as the sole carbon and energy source was identified as… Expand
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2004
2004
Evaluation of clastogenic potential of the antimalarial plant Solanum nudum
Compounds isolated from Solanum nudum have shown in vitro antimalarial activity against the FCB‐2 strain of Plasmodium falciparum… Expand
2003
2003
Evaluation of the mutagenicity of antimalarial products isolated from Solanum nudum (Solanaceae).
Diosgenone is a major component of the hexane extract from the plant Solanum nudum (Solanaceae). The products from degraded and… Expand
2002
2002
Preparations of heterospirostanols and their pharmacological activities.
(3beta,20S,22S,25R)-22-Thiospirosol-5-en-3-ol (9) and (3beta,20S,22S,25R)-22-seleno-spirosol-5-en-3-ol (11) were prepared from… Expand
2002
2002
Low Temperature Crystal Structure of Natural Diosgenone
The molecular structure of diosgenone, a natural steroidal sapogenin, closely related to diosgenin and isolated from Solanum… Expand
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1985
1985
The use of a hydrophobic resin as a product reservoir in steroid transformations
Particles of the hydrophobic resin polydimethylsiloxane were found to preferentially accumulate steriods on the basis of their… Expand
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