digeranyl bisphosphonate

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2007-2017
01220072017

Papers overview

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2017
2017
Bisphosphonates are diphosphate analogs that inhibit the intermediate enzymes of the mevalonate pathway. Here, we compared the… (More)
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2015
2015
Fibrotic remodeling in lung injury is a major cause of morbidity. The mechanism that mediates the ongoing fibrosis is unclear… (More)
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2015
2015
Statins and nitrogenous bisphosphonates (NBPs) are clinically used inhibitors of the mevalonate pathway, which is the pathway… (More)
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2011
2011
Multiple studies have implicated the depletion of isoprenoid biosynthetic pathway intermediates in the induction of autophagy… (More)
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2011
2011
Statins, drugs commonly used to lower serum cholesterol, have been shown to stimulate osteoblast differentiation and bone… (More)
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2010
2010
Geminal bisphosphonates display varied biological activity depending on the nature of the substituents on the central carbon atom… (More)
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2010
2010
The objective of this study was to determine whether geranylgeranyl diphosphate synthase inhibition, and therefore geranylgeranyl… (More)
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2008
2008
Inhibitors of isoprenoid synthesis are widely used for treatment of human diseases, including hypercholesterolemia and… (More)
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2007
2007
A primary cellular target of the clinical nitrogenous bisphosphonates is the isoprenoid biosynthetic pathway. Specifically these… (More)
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