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diazohydroxide

National Institutes of Health

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pyrazine-2-diazohydroxide

Papers overview

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2014
2014
Formation of diazohydroxides ArN 2 OH in aqueous acid solution : polarographic determination of the equilibrium constant K R for the reaction of 4-substituted arenediazonium ions with H 2 O †
In aqueous acid (pH <4) solutions, in the dark, and in the absence of reductants, arenediazonium ions, ArN2 + decompose… 
2007
2007
Development of liquid chromatography electrospray ionization tandem mass spectrometry methods for analysis of DNA adducts of formaldehyde and their application to rats treated with N…
Reaction of formaldehyde with DNA in vitro produces a variety of adducts among which are observed the cross-link di-(N(6… 
2004
2004
Phase II trial of pyrazine diazohydroxide in androgen-independent prostate cancer
No effective therapy has been demonstrated for hormone refractory prostate cancer (HRPC). Pyrazine diazohydroxide (PZDH) is a… 
2002
2002
A Phase II Trial of Pyrazine Diazohydroxide in Patients with Disseminated Malignant Melanoma and no Prior Chemotherapy – Southwest Oncology Group Study
Malignant melanoma is rapidly increasing inthe United States. Metastatic diseaseresponds poorly to currently… 
1987
1987
Nitrosamine carcinogen activation pathway determined by quantum chemical methods.
Multiple reactions are thought to be involved in transforming dialkynitrosamines to active carcinogens. The first proposed step… 
1986
1986
Gas chromatographic assay for the new antitumor agent pyrazine-2-diazohydroxide (diazohydroxide) and its stability in buffer, blood and plasma.
1979
1979
Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Nature of the intermediates from nitrosourea decomposition.
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