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diaminoquinazoline

 
National Institutes of Health

Papers overview

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2019
2019
Antibiotic resistance in Acinetobacter baumannii is a major global health threat. New drugs with novel chemical structures are… Expand
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2018
2018
Diaminoquinazolines represent a privileged scaffold for antimalarial discovery, including use as putative Plasmodium histone… Expand
2018
2018
The diaminoquinazoline series has good potency against Mycobacterium tuberculosis. Resistant isolates have mutations in Rv3161c… Expand
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Highly Cited
2015
Highly Cited
2015
This work describes the first rational targeting of tyrosine residues in a protein binding site by small-molecule covalent probes… Expand
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Highly Cited
2014
Highly Cited
2014
A new series of dihydrofolate reductase (DHFR) inhibitors, the 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines, were designed and… Expand
2014
2014
Modulating epigenetic mechanisms in malarial parasites is an emerging avenue for the discovery of novel antimalarial drugs… Expand
2012
2012
More than 50 new diaminoquinazoline derivatives have been synthesized and evaluated in a colon carcinoma cell growth inhibition… Expand
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Highly Cited
1998
Highly Cited
1998
Binding energy calculations for complexes of mutant and wild-type human dihydrofolate reductases with 2,4-diaminopteridine and 2… Expand
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1994
1994
The mechanism by which P-glycoprotein (P-gp) interacts with a number of structurally unrelated substrates or inhibitors remains… Expand