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diaminoquinazoline
National Institutes of Health
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Trimetrexate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Diaminoquinazoline MMV675968 from Pathogen Box inhibits Acinetobacter baumannii growth through targeting of dihydrofolate reductase
Warangkhana Songsungthong
,
S. Yongkiettrakul
,
+4 authors
U. Leartsakulpanich
Scientific Reports
2019
Corpus ID: 204942395
Antibiotic resistance in Acinetobacter baumannii is a major global health threat. New drugs with novel chemical structures are…
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2018
2018
Development of a Photo-Cross-Linkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium falciparum.
Alexandra Lubin
,
A. Rueda-Zubiaurre
,
+9 authors
M. J. Fuchter
ACS infectious diseases
2018
Corpus ID: 4776247
Diaminoquinazolines represent a privileged scaffold for antimalarial discovery, including use as putative Plasmodium histone…
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2018
2018
Activation of 2,4-Diaminoquinazoline in Mycobacterium tuberculosis by Rv3161c, a Putative Dioxygenase
Eduard Melief
,
S. Bonnett
,
E. Zuniga
,
T. Parish
Antimicrobial Agents and Chemotherapy
2018
Corpus ID: 53097896
The diaminoquinazoline series has good potency against Mycobacterium tuberculosis. Resistant isolates have mutations in Rv3161c…
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Highly Cited
2015
Highly Cited
2015
Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.
E. Hett
,
H. Xu
,
+10 authors
L. Jones
ACS chemical biology
2015
Corpus ID: 206872031
This work describes the first rational targeting of tyrosine residues in a protein binding site by small-molecule covalent probes…
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Highly Cited
2014
Highly Cited
2014
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.
Thanh Lam
,
M. Hilgers
,
+8 authors
J. Finn
Journal of medicinal chemistry
2014
Corpus ID: 45549035
A new series of dihydrofolate reductase (DHFR) inhibitors, the 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines, were designed and…
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2014
2014
Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood‐Stage Antimalarial Compounds
Sandeep Sundriyal
,
Nicholas A Malmquist
,
+8 authors
M. J. Fuchter
ChemMedChem
2014
Corpus ID: 41826422
Modulating epigenetic mechanisms in malarial parasites is an emerging avenue for the discovery of novel antimalarial drugs…
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2012
2012
Design, synthesis, and biological evaluation of new diaminoquinazolines as β-catenin/Tcf4 pathway inhibitors.
Yongjun Mao
,
N. Lin
,
+4 authors
J. An
Journal of medicinal chemistry
2012
Corpus ID: 39173296
More than 50 new diaminoquinazoline derivatives have been synthesized and evaluated in a colon carcinoma cell growth inhibition…
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Highly Cited
1998
Highly Cited
1998
Computation of affinity and selectivity: Binding of 2,4-diaminopteridine and 2,4-diaminoquinazoline inhibitors to dihydrofolate reductases
J. Marelius
,
M. Graffner-Nordberg
,
T. Hansson
,
A. Hallberg
,
J. Åqvist
J. Comput. Aided Mol. Des.
1998
Corpus ID: 15687629
Binding energy calculations for complexes of mutant and wild-type human dihydrofolate reductases with 2,4-diaminopteridine and 2…
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1994
1994
Structurally distinct MDR modulators show specific patterns of reversal against P-glycoproteins bearing unique mutations at serine939/941.
S. Kajiji
,
J. A. Dreslin
,
K. Grizzuti
,
P. Gros
Biochemistry
1994
Corpus ID: 1627232
The mechanism by which P-glycoprotein (P-gp) interacts with a number of structurally unrelated substrates or inhibitors remains…
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1977
1977
Potent inhibitory activity of trimethoxyquine (tmq), "nonclassical" 2,4, diaminoquinazoline, on mammalian dna synthesis. Abstr.
J. Bertino
,
W. L. Sawicki
1977
Corpus ID: 82465749
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