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diaminoquinazoline

 
National Institutes of Health

Papers overview

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2019
2019
Antibiotic resistance in Acinetobacter baumannii is a major global health threat. New drugs with novel chemical structures are… Expand
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2018
2018
The diaminoquinazoline series has good potency against Mycobacterium tuberculosis Resistant isolates have mutations in Rv3161c, a… Expand
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2018
2018
Diaminoquinazolines represent a privileged scaffold for antimalarial discovery, including use as putative Plasmodium histone… Expand
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2017
2017
Plasmodium falciparum HKMTs (PfHKMTs) play a key role in controlling Plasmodium gene expression and represent exciting new anti… Expand
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2015
2015
This work describes the first rational targeting of tyrosine residues in a protein binding site by small-molecule covalent probes… Expand
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2014
2014
A new series of dihydrofolate reductase (DHFR) inhibitors, the 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines, were designed and… Expand
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2014
2014
Modulating epigenetic mechanisms in malarial parasites is an emerging avenue for the discovery of novel antimalarial drugs… Expand
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2012
2012
More than 50 new diaminoquinazoline derivatives have been synthesized and evaluated in a colon carcinoma cell growth inhibition… Expand
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1998
1998
Binding energy calculations for complexes of mutant and wild-type human dihydrofolate reductases with 2,4-diaminopteridine and 2… Expand
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