diaminoquinazoline
National Institutes of Health
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Antibiotic resistance in Acinetobacter baumannii is a major global health threat. New drugs with novel chemical structures are…
Diaminoquinazolines represent a privileged scaffold for antimalarial discovery, including use as putative Plasmodium histone…
The diaminoquinazoline series has good potency against Mycobacterium tuberculosis. Resistant isolates have mutations in Rv3161c…
This work describes the first rational targeting of tyrosine residues in a protein binding site by small-molecule covalent probes…
A new series of dihydrofolate reductase (DHFR) inhibitors, the 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines, were designed and…
Modulating epigenetic mechanisms in malarial parasites is an emerging avenue for the discovery of novel antimalarial drugs…
More than 50 new diaminoquinazoline derivatives have been synthesized and evaluated in a colon carcinoma cell growth inhibition…
Binding energy calculations for complexes of mutant and wild-type human dihydrofolate reductases with 2,4-diaminopteridine and 2…
The mechanism by which P-glycoprotein (P-gp) interacts with a number of structurally unrelated substrates or inhibitors remains…