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detorubicin

Known as: Diethoxy-,2-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-oxoethyl ester,(2S-cis) Acetic Acid, 14-diethoxyacetoxydaunorubicin, detrorubicin 
A semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with… Expand
National Institutes of Health

Papers overview

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Review
1988
Review
1988
The treatment of patients with metastatic melanoma remains a difficult problem. It is clear that more effective agents need to be… Expand
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1985
1985
Between January 1981 and December 1983, a prospective therapeutic trial of detorubicin (14-diethoxyacetoxy-daunorubicin [DTR… Expand
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1985
1985
A phase II study of detorubicin, the semisynthetic 14-diethoxyacetoxy ester of daunorubicin, was conducted in 42 patients with… Expand
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1984
1984
Detorubicin (DET), a semi-synthetic analog of daunorubicin, releases at neutral pH doxorubicin (DOX) upon hydrolysis. DET enters… Expand
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1984
1984
Golden hamsters were submitted, three times a week during 4 weeks, to i.p. administration of an antracenedione, mitoxantrone (MTX… Expand
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1982
1982
51 patients with malignant melanomas who had not previously received chemotherapy were studied in a phase III trial. They were… Expand
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1982
1982
SummaryIn an attempt to establish a relationship between the pharmacokinetics in mouse heart of new anthracycline derivatives and… Expand
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1980
1980
Six anthracycline antibiotics with demonstrated antitumor activity in human or experimental tumor systems were studied. The… Expand
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1979
1979
Golden hamsters received Adriamycin (ADR), detorubicin (DTR), AD-32, or aclacinomycin (ACM) three times weekly at doses… Expand
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1979
1979
The anthracycline derivatives are intercalating drugs which are of major importance in the treatment of leukemias and in the… Expand
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