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detorubicin

Known as: Diethoxy-,2-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-oxoethyl ester,(2S-cis) Acetic Acid, 14-diethoxyacetoxydaunorubicin, detrorubicin 
A semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with… 
National Institutes of Health

Related topics

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3 relations

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33921 RP

Broader (1)

Daunorubicin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Current concepts in chemotherapy for malignant pleural mesothelioma
Objectives:  The aim of this study was to provide an overview of the most active single agents and combination regimens in… 
Review
1988
Review
1988
Systemic chemotherapy for metastatic melanoma.
The treatment of patients with metastatic melanoma remains a difficult problem. It is clear that more effective agents need to be… 
1985
1985
Detorubicin--an active anthracycline in untreated metastatic melanoma.
A phase II study of detorubicin, the semisynthetic 14-diethoxyacetoxy ester of daunorubicin, was conducted in 42 patients with… 
1984
1984
Comparative microscopic study of cardiotoxicity and skin toxicity of anthracycline analogs.
Golden hamsters were submitted, three times a week during 4 weeks, to i.p. administration of an antracenedione, mitoxantrone (MTX… 
1983
1983
Mutagenicity of eight anthracycline derivatives in five strains of Salmonella typhimurium.
1982
1982
[Chemotherapy in advanced malignant melanoma. Results of a controlled trial comparing a combination of dacarbazine (DTIC) and detorubicin with dacarbazine alone].
51 patients with malignant melanomas who had not previously received chemotherapy were studied in a phase III trial. They were… 
Highly Cited
1980
Highly Cited
1980
Cardiotoxicity and comparative pharmacokinetics of six anthracyclines in the rabbit.
Six anthracycline antibiotics with demonstrated antitumor activity in human or experimental tumor systems were studied. The… 
Highly Cited
1979
Highly Cited
1979
Electron microscopic studies of the heart and light microscopic studies of the skin after treatment of golden hamsters with adriamycin, detorubicin, AD-32, and aclacinomycin.
Golden hamsters received Adriamycin (ADR), detorubicin (DTR), AD-32, or aclacinomycin (ACM) three times weekly at doses… 
1979
1979
Clinical activity of detorubicin: a new anthracycline derivative.
The anthracycline derivatives are intercalating drugs which are of major importance in the treatment of leukemias and in the… 
1979
1979
Pharmacokinetic, toxicologic, and chemotherapeutic properties of detorubicin in mice: a comparative study with daunorubicin and adriamycin.
We have studied the stability, pharmacology, toxicology, and therapeutic activity in mice of detorubicin, a new semisynthetic… 
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