detorubicin

Known as: Diethoxy-,2-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-oxoethyl ester,(2S-cis) Acetic Acid, 14-diethoxyacetoxydaunorubicin, detrorubicin 
A semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with… (More)

Topic mentions per year

Topic mentions per year

1978-2008
024619782008

Papers overview

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1991
1991
Several new investigational agents have shown some promise in the treatment of patients with disseminated melanoma. While earlier… (More)
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1985
1985
Between January 1981 and December 1983, a prospective therapeutic trial of detorubicin (14-diethoxyacetoxy-daunorubicin [DTR… (More)
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1985
1985
A phase II study of detorubicin, the semisynthetic 14-diethoxyacetoxy ester of daunorubicin, was conducted in 42 patients with… (More)
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1982
1982
51 patients with malignant melanomas who had not previously received chemotherapy were studied in a phase III trial. They were… (More)
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1982
1982
In an attempt to establish a relationship between the pharmacokinetics in mouse heart of new anthracycline derivatives and their… (More)
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1981
1981
In a randomized multicenter trial, 151 patients, with advanced epidermoid carcinoma of the head, neck and oesophagus, were… (More)
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1980
1980
Six anthracycline antibiotics with demonstrated antitumor activity in human or experimental tumor systems were studied. The… (More)
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1979
1979
Golden hamsters received Adriamycin (ADR), detorubicin (DTR), AD-32, or aclacinomycin (ACM) three times weekly at doses… (More)
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1979
1979
The anthracycline derivatives are intercalating drugs which are of major importance in the treatment of leukemias and in the… (More)
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1979
1979
We have studied the stability, pharmacology, toxicology, and therapeutic activity in mice of detorubicin, a new semisynthetic… (More)
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