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detorubicin

Known as: Diethoxy-,2-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-oxoethyl ester,(2S-cis) Acetic Acid, 14-diethoxyacetoxydaunorubicin, detrorubicin 
A semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin. Detorubicin intercalates into DNA and interacts with… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
SummaryA phase II trial of which preliminary results are available for 22 patients indicates that aclacinomycin applied in a… Expand
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Review
1988
Review
1988
The treatment of patients with metastatic melanoma remains a difficult problem. It is clear that more effective agents need to be… Expand
1985
1985
Between January 1981 and December 1983, a prospective therapeutic trial of detorubicin (14‐diethoxyacetoxy‐daunorubicin [DTR… Expand
1985
1985
A phase II study of detorubicin, the semisynthetic 14-diethoxyacetoxy ester of daunorubicin, was conducted in 42 patients with… Expand
1984
1984
Detorubicin (DET), a semi-synthetic analog of daunorubicin, releases at neutral pH doxorubicin (DOX) upon hydrolysis. DET enters… Expand
1982
1982
51 patients with malignant melanomas who had not previously received chemotherapy were studied in a phase III trial. They were… Expand
Highly Cited
1980
Highly Cited
1980
Six anthracycline antibiotics with demonstrated antitumor activity in human or experimental tumor systems were studied. The… Expand
Highly Cited
1979
Highly Cited
1979
Golden hamsters received Adriamycin (ADR), detorubicin (DTR), AD-32, or aclacinomycin (ACM) three times weekly at doses… Expand
1979
1979
The anthracycline derivatives are intercalating drugs which are of major importance in the treatment of leukemias and in the… Expand
1979
1979
We have studied the stability, pharmacology, toxicology, and therapeutic activity in mice of detorubicin, a new semisynthetic… Expand