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detirelix

Known as: LHRH, N-acetyl-3-(2-naphthyl)-Ala(1)-4-Cl-Phe(2)-Trp(3)-Et2-hArg(6)-AlaNH2(10)-, LHRH, N-acetyl-2-naphthylalanyl(1)-4-chlorophenylalanyl(2)-tryptophyl(3)-diethylhomoarginyl(6)-alaninamide(10)-, GnRH, N-acetyl-3-(2-naphthyl)-Ala(1)-4-Cl-Phe(2)-Trp(3)-Et2-hArg(6)-AlaNH2(10)- 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Gonadorelin

Narrower (1)

RS 68439
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Effects of GnRH analogues on pituitary\p=n-\testicular function in free-ranging African elephants (Loxodonta africana)
We tested the ability of several GnRH analogues to suppress pituitary\p=n-\testicular activity and potentially musth in free… 
1994
1994
Pulmonary Delivery of Detirelix by Intratracheal Instillation and Aerosol Inhalation in the Briefly Anesthetized Dog
Pulmonary delivery of the decapeptide detirelix was studied in briefly anesthetized dogs and the pharmacokinetics were examined… 
1994
1994
Pharmacokinetics of Detirelix Following Intratracheal Instillation and Aerosol Inhalation in the Unanesthetized Awake Sheep
The unanesthetized awake sheep was employed as large animal model for the determination of bioavailability and pharmacokinetics… 
1992
1992
Concordant suppression of serum immunoreactive luteinizing hormone (LH), follicle-stimulating hormone, alpha subunit, bioactive LH, and testosterone in postmenopausal women by a potent gonadotropin…
The purposes of the current study were 2-fold: 1) to assess the effects of a new antagonistic analog of GnRH [N-Ac-D-Nal(2)1, D… 
1991
1991
Effect of late follicular phase administration of antide on ovulation and inhibin secretion in macaques.
Highly Cited
1991
Highly Cited
1991
Variable ovarian response to gonadotropin-releasing hormone antagonist-induced gonadotropin deprivation during different phases of the menstrual cycle.
The gonadotropin dependence of ovarian follicular maturation and corpus luteum function can now be examined in women using… 
Highly Cited
1990
Highly Cited
1990
Gonadotropin subunit messenger RNA concentrations after blockade of gonadotropin-releasing hormone action: testosterone selectively increases follicle-stimulating hormone beta-subunit messenger RNA…
Regulation of gonadotropin gene expression by sex steroids may occur via direct effects on the pituitary and/or indirect effects… 
1990
1990
Inhibitory effects of treatment with an LHRH antagonist on the ovulatory cycle are reduced when administered during the late follicular phase.
1988
1988
Potent, long-acting luteinizing hormone-releasing hormone antagonists containing new synthetic amino acids: N,N'-dialkyl-D-homoarginines.
A new series of unnatural amino acids has been prepared and incorporated into antagonistic analogues of luteinizing hormone… 
Highly Cited
1987
Highly Cited
1987
Suppression of pituitary-gonadal function by a potent new luteinizing hormone-releasing hormone antagonist in normal men.
LHRH antagonists compete with endogenous LHRH for binding to receptors on pituitary gonadotrophs and thereby inhibit gonadal… 
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