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destruxin B

 
National Institutes of Health

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Depsipeptides

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2014
2014
Destruxin B inhibits hepatocellular carcinoma cell growth through modulation of the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition.
The aberrant activation of Wnt/β-catenin signaling plays an important role in the carcinogenesis and progression of… Expand
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2013
2013
Destruxin B Isolated from Entomopathogenic Fungus Metarhizium anisopliae Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in Human Nonsmall Cell Lung Cancer Cells
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and… Expand
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2012
2012
Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging.
In continuation to our studies toward the identification of direct anti-cancer targets, here we showed that destruxin B (DB) from… Expand
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2012
2012
In vitro and in vivo anticancer effects of destruxin B on human colorectal cancer.
AIM The study of the anticancer effects of destruxin B (DB) is rare and its anticancer mechanism remains unknown. The aim of this… Expand
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2003
2003
Destruxins, cyclodepsipeptides, block the formation of actin rings and prominent clear zones and ruffled borders in osteoclasts.
Bone-resorbing osteoclasts exhibit polarized morphological structures such as actin rings, clear zones, and ruffled borders. To… Expand
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2000
2000
Comparison of the phytotoxic activity of the phytotoxin destruxin B and four natural analogs.
A quantitative bioassay utilizing staining of plant cell suspension cultures of Sinapis alba was employed to establish a… Expand
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2000
2000
Vital staining of plant cell suspension cultures: evaluation of the phytotoxic activity of the phytotoxins phomalide and destruxin B
Abstract A cell suspension culture assay to determine the phytotoxicity of the fungal toxins phomalide, a host-selective toxin… Expand
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1997
1997
Suppressive effects of destruxin B on hepatitis B virus surface antigen gene expression in human hepatoma cells.
Destruxin B, a cyclodepsipeptide was originally identified as a plant pathogen from the fungus, Alternaria brassicae. We examined… Expand
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1994
1994
Destruxin B, a specific and readily reversible inhibitor of vacuolar-type H(+)-translocating ATPase.
Destruxin B, a peptide antibiotic, inhibits vacuolar-type ATPase (V-ATPase) specifically and dose-dependently among ATPases… Expand
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1990
1990
omega-Conotoxin GVIA and nifedipine inhibit the depolarizing action of the fungal metabolite, destruxin B on muscle from the tobacco budworm (Heliothis virescens).
Recent studies on a group of fungal metabolites, collectively called the destruxins, have suggested that these compounds activate… Expand
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