• Corpus ID: 839057

Non-cyclic AMP-dependent, positive inotropic cyclodepsipeptides with negative chronotropy.

@article{Tsunoo1999NoncyclicAP,
  title={Non-cyclic AMP-dependent, positive inotropic cyclodepsipeptides with negative chronotropy.},
  author={Akinobu Tsunoo and Masayuki Kamijo},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={290 3},
  pages={
          1006-12
        }
}
  • A. Tsunoo, M. Kamijo
  • Published 1 September 1999
  • Medicine, Chemistry
  • The Journal of pharmacology and experimental therapeutics
The effects of natural cyclodepsipeptides (CDPs) on isolated rat cardiac tissue preparations were examined in vitro. Destruxin A, destruxin B (DB), roseotoxin B (RB), and roseocardin (RC), a novel CDP, each caused a concentration-dependent increase in the contraction force of the right atrium and the papillary and trabecular muscles of the right ventricle at 0.6 to 600 microM. RB, destruxin A, and DB did not affect the half-decay time of relaxation of the papillary muscles, but RC slightly… 
Callipeltin A: sodium ionophore effect and tension development in vascular smooth muscle.
TLDR
It is suggested that the effect of callipeltin A on cardiac and vascular preparations is linked to a Na-ionophore action.
Callipeltin A, a cyclic depsipeptide inhibitor of the cardiac sodium-calcium exchanger and positive inotropic agent.
TLDR
It is suggested that the positive inotropic effect is linked to the inhibition of the Na(+)/Ca(2+) exchanger and that Callipeltin A may be an useful tool to study the role of the cardiac Na(+, Ca(2%) exchanger in physiological and pathological conditions.
Inotropic and chronotropic effects of 6-hydroxy-4-methylquinolin-2(1H)-one derivatives in isolated rat atria.
TLDR
This study provides functional evidence for the positive inotropic effect of C6, and concludes that C6 produces its effect via potentiation of cAMP-dependent signaling system and possibly by inhibition of PDE3 activity.
Effects of the mycotoxin destruxin A on Locusta migratoria visceral muscles.
TLDR
Results show that destruxin A has an excitatory effect on contractions of insect visceral muscles of L. migratoria, which suggest that this peptide toxin might be acting on insect visceral muscle by facilitating an influx of extracellular Ca(2+).
Destruxins, cyclodepsipeptides, block the formation of actin rings and prominent clear zones and ruffled borders in osteoclasts.
TLDR
The results suggest that the anti-resorptive effects of destruxins result from induction of a disorder of the morphological structures in polarized OCLs.
Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells
Identifying effective anti-fibrotic therapies is a major clinical need that remains unmet. In the present study, roseotoxin B was shown to possess an improving effect on cholestatic liver fibrosis in
Cyclodepsipeptides - potential drugs and lead compounds in the drug development process.
TLDR
A number of cyclodepsipeptides from marine sponges, bacteria and fungi have been identified, and the scope of activity spans a range from cytoprotective activity against HIV-1 infection, growth inhibitory effects toward cancer cells, and antimycobacterial, and antimalarial activity.
Probing inhibitory effects of destruxins from Metarhizium anisopliae using insect cell based impedance spectroscopy: inhibition vs chemical structure.
A noninvasive technique based on electric cell-substrate impedance sensing (ECIS) was demonstrated for on-line probing inhibitory effects of five destruxins on Spodoptera frugiperda Sf9 insect cells.
The destruxins: synthesis, biosynthesis, biotransformation, and biological activity.
TLDR
Reports on isolation, chemical structure determination, total synthesis, transformation by diverse organisms, and biological activity of destruxins and related metabolites are reviewed for the first time.
Destruxin from Metarhizium anisopliae induces oxidative stress effecting larval mortality of the polyphagous pest Spodoptera litura
TLDR
There was a considerable hike in the activity of lipoxygenase and lipid peroxidation levels in the treated larvae with increased time of exposure to mycotoxin, suggesting that exposure of larvae to crude dtx induces oxidative stress which is countered by the antioxidant enzymes to an extent governed by the concentration and time of treatment, beyond which the larvae succumb to the ecofriendly biotoxin.
...
1
2
...

References

SHOWING 1-10 OF 51 REFERENCES
Positive inotropic effects of the calcium sensitizer CGP 48506 in guinea pig myocardium.
TLDR
CGP 48506 is the first pharmacological agent with noteworthy calcium-sensitizing properties that has been found to be devoid of inhibitory activity on cardiac PDE.
The Two Mechanisms of Action of Racemic Cardiotonic EMD 53998, Calcium Sensitization and Phosphodiesterase Inhibition, Reside in Different Enantiomers
TLDR
It is concluded that one of the two different mechanisms underlying the overall positive inotropic activity of EMD 53 998 can be assigned, almost exclusively, to one ofThe two enantiomer EMD 57 033 is unique in possessing both a high absolute potency at the level of the contractile elements and a favorable relation of Ca2+ sensitization to PDE inhibition.
Cardiotonic Activity of Amrinone–Win 40680 [5‐Amino‐3,4f‐bipyridin‐6(lH)‐one]
TLDR
The cardiotonic activity of a new, noncatechol, nonglycoside agent, amrinone, was investigated in vitro and in anesthestized and unanesthetized dogs and produced a positive inotropic effect with a rapid onset and long duration of action.
Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium.
TLDR
CGP 48506 is the first inotropic agent with calcium-sensitizing properties in the human heart that has been found to be devoid of inhibitory activity on human cardiac PDE isoenzymes.
The role of cyclic AMP in isoprenaline‐induced cardiac necroses in the rat *
  • P. Martorana
  • Medicine
    The Journal of pharmacy and pharmacology
  • 1971
TLDR
A mediatory role for cyclic AMP in the isoprenaline‐induced cardiac necroses in the rat is suggested and it is suggested that the percentage of animals affected was not dose‐dependent.
EMD 53998 sensitizes the contractile proteins to calcium in intact ferret ventricular muscle.
TLDR
EMD 53998 is the first agent for which much of the inotropic effect in intact cardiac muscle can be accounted for by increased Ca2+ sensitivity of the contractile proteins.
Cyclic AMP and the pathogenesis of myocardial injury.
  • J. Lee, S. Downing
  • Medicine
    Research communications in chemical pathology and pharmacology
  • 1980
TLDR
It is suggested that excessive stimulation of the cyclase system can serve as a common mechanism in the pathogensis of myocardial damage by a broad spectrum stimuli.
Cyclic AMP and the pathogenesis of myocardial injury.
: Rabbits were given N6, O2, dibutyryl 3', 5' - cyclic AMP DB-cAMP), 2.5 micrograms/kg/min, i.v. for 90 min. to determine if activation of the cyclic neucleotide system is a potential cause of
Ca++ sensitizers impair cardiac relaxation in failing human myocardium.
TLDR
The Ca++ sensitizers EMD 57033 and ORG 30029 increased active force development in nonfailing and failing human myocardium, but both impaired relaxation in failing myocardial fibers to a greater extent than inNonfailing humanMyocardium in a concentration-dependent fashion.
Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway.
TLDR
NE, acting via the ss-adrenergic pathway, stimulates apoptosis in adult rat cardiac myocytes in vitro and requires calcium entry via voltage-dependent calcium channels, which may contribute to the progression of myocardial failure.
...
1
2
3
4
5
...