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desmethylazelastine

Known as: 4-(4-chlorobenzyl)-2-(perhydroazepinyl-(4))-1(2H)-phthala zinone 
National Institutes of Health

Papers overview

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Review
2012
Review
2012
SummaryConclusion: Twice-daily intranasal azelastine offers an effective and well tolerated alternative to other antihistamine… Expand
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Highly Cited
2001
Highly Cited
2001
It is generally known that the substrates and/or inhibitors of cytochrome P450 (CYP) 3A4 and P-glycoprotein (P-gp) overlap with… Expand
Highly Cited
1999
Highly Cited
1999
Azelastine, an antiallergy and antiasthmatic drug, has been reported to be mainly N-demethylated to desmethylazelastine in humans… Expand
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1999
1999
Azelastine, an antiallergy and antiasthmatic drug, has been reported to be metabolized mainly to desmethylazelastine and 6… Expand
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1999
1999
Azelastine hydrochloride [4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4yl )-1-(2 H)-phthalazinone… Expand
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1993
1993
Analytical methods have been developed for the simultaneous quantitation of azelastine (AZ) and desmethylazelastine (DAZ) in… Expand
1993
1993
The correlation between the antiasthma activity of azelastine and the concentrations of azelastine and its major metabolite… Expand
1992
1992
Pharmacokinetics of azelastine (AZ) and its major active metabolite desmethylazelastine (DAZ) after iv or po administration of 1… Expand
1990
1990
We examined the effects of a new anti-asthmatic drug, azelastine, and its principal metabolite, desmethylazelastine, on the in… Expand
1987
1987
A manual-injection liquid chromatographic method using fluorescence detection permitted determination of a new antiasthmatic drug… Expand