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derrubone

 
National Institutes of Health

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Broader (1)

Isoflavones

Papers overview

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2020
2020
Three isoflavones from Derris scandens (Roxb.) Benth and their cancer chemopreventive activity and in vitro antiproliferative effects.
Three undescribed isoflavones, derriscandenon A, B, and C, together with seven known isoflavones were isolated and structurally… Expand
2015
2015
In-silico modeling studies of G-quadruplex with soy isoflavones having anticancerous activity
  • J. Tomar
  • Journal of Molecular Modeling
  • 2015
    • Corpus ID: 25136094
Telomere forms t-loop and G-quadruplex as the protective structure and the formation of these structures hinder the telomerase… Expand
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2014
2014
Identifying a C-terminal ATP binding sites-based novel Hsp90-Inhibitor in silico: a plausible therapeutic approach in Alzheimer's disease.
BACKGROUND Alzheimer's disease (AD) is a progressive brain disorder, which gradually and irreversibly destroys the intellectual… Expand
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2014
2014
Identification and inhibition of C-terminal ATP-binding sites of Hsp90α through design of novel derrubone analogues as a plausible approach towards Alzheimer’s disease treatment
The significant causative factors of Alzheimer's disease progression is the failure of the heat shock protein Hsp-90 to… Expand
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2010
2010
The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone.
The natural products novobiocin and derrubone have both demonstrated Hsp90 inhibition and structure-activity relationships have… Expand
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2008
2008
Synthesis and evaluation of derrubone and select analogues.
Recently, we reported that the natural product derrubone exhibits Hsp90 inhibitory activity. Due to its unique architectural… Expand
2007
2007
Derrubone, an inhibitor of the Hsp90 protein folding machinery.
High-throughput screening of a library of diverse molecules has identified derrubone ( 1), an isoflavone natural product from… Expand
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