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derrubone

 
National Institutes of Health

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Isoflavones

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2015
2015
In-silico modeling studies of G-quadruplex with soy isoflavones having anticancerous activity
Telomere forms t-loop and G-quadruplex as the protective structure and the formation of these structures hinder the telomerase… Expand
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2014
2014
Identifying a C-terminal ATP binding sites-based novel Hsp90-Inhibitor in silico: a plausible therapeutic approach in Alzheimer's disease.
BACKGROUND Alzheimer's disease (AD) is a progressive brain disorder, which gradually and irreversibly destroys the intellectual… Expand
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2014
2014
Identification and inhibition of C-terminal ATP-binding sites of Hsp90α through design of novel derrubone analogues as a plausible approach towards Alzheimer’s disease treatment
The significant causative factors of Alzheimer's disease progression is the failure of the heat shock protein Hsp-90 to… Expand
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2010
2010
The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone.
The natural products novobiocin and derrubone have both demonstrated Hsp90 inhibition and structure-activity relationships have… Expand
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2008
2008
Synthesis and evaluation of derrubone and select analogues.
Recently, we reported that the natural product derrubone exhibits Hsp90 inhibitory activity. Due to its unique architectural… Expand
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2007
2007
Derrubone, an inhibitor of the Hsp90 protein folding machinery.
High-throughput screening of a library of diverse molecules has identified derrubone ( 1), an isoflavone natural product from… Expand
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