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deoxyhypusine

Known as: L-Lysine, N6-(4-aminobutyl)-, N(6)-(4-aminobutyl)lysine 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Lysine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria—inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase
Malaria is still a major cause of death in the tropics. There is an urgent need for new anti-malarial drugs because drug… 
Highly Cited
2007
Highly Cited
2007
Role of Hypusinated Eukaryotic Translation Initiation Factor 5A in Polyamine Depletion-induced Cytostasis*
We have earlier shown that α-methylated spermidine and spermine analogues rescue cells from polyamine depletion-induced growth… 
Highly Cited
2007
Highly Cited
2007
Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth
The eukaryotic translation initiation factor 5A (eIF5A) undergoes a specific post‐translational modification called hypusination… 
1997
1997
Enzyme-Substrate Intermediate Formation at Lysine 329 of Human Deoxyhypusine Synthase*
Deoxyhypusine (N ε-(4-aminobutyl)lysine) is the key intermediate in the posttranslational synthesis of the unique amino acid… 
1997
1997
Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification.
Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor represents a unique posttranslational modification… 
Highly Cited
1996
Highly Cited
1996
Deoxyhypusine synthase gene is essential for cell viability in the yeast Saccharomyces cerevisiae
1994
1994
Deoxyhypusine synthase assay based on the use of polyhistidine-tagged substrate and metal chelate-affinity chromatography.
Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor is a unique spermidine-dependent post-translational… 
Highly Cited
1992
Highly Cited
1992
Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion.
The effects of inhibition of the capacity to form spermidine and spermine on cell growth were investigated using murine leukaemia… 
Highly Cited
1986
Highly Cited
1986
Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization.
Highly Cited
1982
Highly Cited
1982
The biosynthesis of protein-bound hypusine (N epsilon -(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon -(4-aminobutyl)lysine…
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