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deoxyhypusine synthase

Known as: DHS, DHPS, EC 2.5.1.46 
Deoxyhypusine synthase (369 aa, ~41 kDa) is encoded by the human DHPS gene. This protein plays a role in the synthesis of deoxyhypusine and the post… Expand
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Under oxidative conditions, 1,4-dihydropyridines (DHPs) undergo a homolytic cleavage, forming exclusively a Csp3-centered radical… Expand
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2009
2009
Deoxyhypusine synthase, an NAD+-dependent enzyme, catalyzes the first step in the post-translational synthesis of an unusual… Expand
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2007
2007
New N-3 functionalized 3,4-dihydropyrimidine-2(1H)-ones with 1,2,4-oxadiazole group as amide isostere were synthesized in six… Expand
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Highly Cited
2004
Highly Cited
2004
In order to improve the nutritional value of rice, we prepared transgenic rice plants with a lysine-feedback-insensitive maize… Expand
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Highly Cited
2002
Highly Cited
2002
The plant enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase (HPPK/DHPS) is a mitochondrial… Expand
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2002
2002
We have determined the relationship between point mutations in the gene that encodes the sulfa target, dihydropteroate synthase… Expand
1999
1999
  • K. Schleifer
  • Journal of medicinal chemistry
  • 1999
  • Corpus ID: 21407750
Via a 3D-QSAR pseudoreceptor modeling approach, atomistic binding site models for pharmacologically active 1,4-dihydropyridines… Expand
1996
1996
Deoxyhypusine synthase is an NAD(+)-dependent enzyme that catalyses the formation of a deoxyhypusine residue on the eukaryotic… Expand
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Highly Cited
1995
Highly Cited
1995
Deoxyhypusine synthase is the first enzyme involved in the post-translational formation of hypusine, a unique amino acid that… Expand
Highly Cited
1995
Highly Cited
1995
The pore-forming α1 subunit of L-type voltage-gated Ca channels contains a Ca-binding site that is allosterically coupled to the… Expand