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deoxyhypusine synthase

Known as: DHS, DHPS, EC 2.5.1.46 
Deoxyhypusine synthase (369 aa, ~41 kDa) is encoded by the human DHPS gene. This protein plays a role in the synthesis of deoxyhypusine and the post… 
National Institutes of Health

Related topics

Related topics

10 relations
Amino Acid BiosynthesisDHPS geneDPYS geneEnzyme Gene

Broader (1)

Oxidoreductases Acting on CH-NH Group Donors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
Deoxyhypusine synthase (DHPS) utilizes spermidine and NAD as cofactors to incorporate a hypusine modification into the eukaryotic… 
2018
2018
DHS (Trans-4,4’-Dihydroxystilbene) Suppresses DNA Replication and Tumor Growth by Inhibiting RRM2 (Ribonucleotide Reductase Regulatory Subunit M2)
DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Since inhibition of DNA… 
2017
2017
trans-4,4’-Dihydroxystilbene (DHS) inhibits human neuroblastoma tumor growth and induces mitochondrial and lysosomal damages in neuroblastoma cell lines
In view of the inadequacy of neuroblastoma treatment, five hydroxystilbenes and resveratrol (Resv) were screened for their… 
Review
2011
Review
2011
Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling
Deoxyhypusine synthase (DHS) catalyzes the post-translational formation of the amino acid hypusine. Hypusine is unique to the… 
Highly Cited
2009
Highly Cited
2009
Identification and Characterization of a Novel Deoxyhypusine Synthase in Leishmania donovani*
Deoxyhypusine synthase, an NAD+-dependent enzyme, catalyzes the first step in the post-translational synthesis of an unusual… 
Highly Cited
2002
Highly Cited
2002
Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities.
The plant enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase (HPPK/DHPS) is a mitochondrial… 
Highly Cited
1999
Highly Cited
1999
Stereoselective characterization of the 1,4-dihydropyridine binding site at L-type calcium channels in the resting state and the opened/inactivated state.
Via a 3D-QSAR pseudoreceptor modeling approach, atomistic binding site models for pharmacologically active 1,4-dihydropyridines… 
1996
1996
Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information.
Deoxyhypusine synthase is an NAD(+)-dependent enzyme that catalyses the formation of a deoxyhypusine residue on the eukaryotic… 
Highly Cited
1995
Highly Cited
1995
Deoxyhypusine Synthase from Rat Testis: Purification and Characterization (*)
Deoxyhypusine synthase is the first enzyme involved in the post-translational formation of hypusine, a unique amino acid that… 
Highly Cited
1995
Highly Cited
1995
Calcium Binding in the Pore of L-type Calcium Channels Modulates High Affinity Dihydropyridine Binding (*)
The pore-forming α1 subunit of L-type voltage-gated Ca channels contains a Ca-binding site that is allosterically coupled to the… 
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