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deoxyhypusine synthase

Known as: DHS, DHPS, EC 2.5.1.46 
Deoxyhypusine synthase (369 aa, ~41 kDa) is encoded by the human DHPS gene. This protein plays a role in the synthesis of deoxyhypusine and the post… 
National Institutes of Health

Related topics

Related topics

10 relations
Amino Acid BiosynthesisDHPS geneDPYS geneEnzyme Gene

Broader (1)

Oxidoreductases Acting on CH-NH Group Donors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
DHS (Trans-4,4’-Dihydroxystilbene) Suppresses DNA Replication and Tumor Growth by Inhibiting RRM2 (Ribonucleotide Reductase Regulatory Subunit M2)
DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Since inhibition of DNA… 
Highly Cited
2017
Highly Cited
2017
Late-Stage C-H Alkylation of Heterocycles and 1,4-Quinones via Oxidative Homolysis of 1,4-Dihydropyridines.
Under oxidative conditions, 1,4-dihydropyridines (DHPs) undergo a homolytic cleavage, forming exclusively a Csp3-centered radical… 
2015
2015
The novel synthesis of magnetically chitosan/carbon nanotube composites and their catalytic applications.
2015
2015
Structural characterization of new Schiff bases of sulfamethoxazole and sulfathiazole, their antibacterial activity and docking computation with DHPS protein structure.
Review
2011
Review
2011
Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling
Deoxyhypusine synthase (DHS) catalyzes the post-translational formation of the amino acid hypusine. Hypusine is unique to the… 
2009
2009
Identification and Characterization of a Novel Deoxyhypusine Synthase in Leishmania donovani*
Deoxyhypusine synthase, an NAD+-dependent enzyme, catalyzes the first step in the post-translational synthesis of an unusual… 
Highly Cited
2004
Highly Cited
2004
Constitutive and seed-specific expression of a maize lysine-feedback-insensitive dihydrodipicolinate synthase gene leads to increased free lysine levels in rice seeds
In order to improve the nutritional value of rice, we prepared transgenic rice plants with a lysine-feedback-insensitive maize… 
Highly Cited
2002
Highly Cited
2002
Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities.
The plant enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase (HPPK/DHPS) is a mitochondrial… 
Highly Cited
1995
Highly Cited
1995
Deoxyhypusine Synthase from Rat Testis: Purification and Characterization (*)
Deoxyhypusine synthase is the first enzyme involved in the post-translational formation of hypusine, a unique amino acid that… 
Highly Cited
1995
Highly Cited
1995
Calcium Binding in the Pore of L-type Calcium Channels Modulates High Affinity Dihydropyridine Binding (*)
The pore-forming α1 subunit of L-type voltage-gated Ca channels contains a Ca-binding site that is allosterically coupled to the… 
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