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deoxyhypusine synthase

Known as: DHS, DHPS, EC 2.5.1.46 
Deoxyhypusine synthase (369 aa, ~41 kDa) is encoded by the human DHPS gene. This protein plays a role in the synthesis of deoxyhypusine and the post… Expand
National Institutes of Health

Related topics

Related topics

10 relations
Amino Acid BiosynthesisDHPS geneDPYS geneEnzyme Gene
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Broader (1)

Oxidoreductases Acting on CH-NH Group Donors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Late-Stage C-H Alkylation of Heterocycles and 1,4-Quinones via Oxidative Homolysis of 1,4-Dihydropyridines.
Under oxidative conditions, 1,4-dihydropyridines (DHPs) undergo a homolytic cleavage, forming exclusively a Csp3-centered radical… Expand
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2009
2009
Identification and Characterization of a Novel Deoxyhypusine Synthase in Leishmania donovani*
Deoxyhypusine synthase, an NAD+-dependent enzyme, catalyzes the first step in the post-translational synthesis of an unusual… Expand
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2007
2007
A new approach to N-3 functionalized 3,4-dihydropyrimidine-2(1H)-ones with 1,2,4-oxadiazole group as amide isostere via ionic liquid-phase technology
New N-3 functionalized 3,4-dihydropyrimidine-2(1H)-ones with 1,2,4-oxadiazole group as amide isostere were synthesized in six… Expand
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Highly Cited
2004
Highly Cited
2004
Constitutive and seed-specific expression of a maize lysine-feedback-insensitive dihydrodipicolinate synthase gene leads to increased free lysine levels in rice seeds
In order to improve the nutritional value of rice, we prepared transgenic rice plants with a lysine-feedback-insensitive maize… Expand
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Highly Cited
2002
Highly Cited
2002
Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities.
The plant enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase (HPPK/DHPS) is a mitochondrial… Expand
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2002
2002
Plasmodium falciparum: in vitro activity of sulfadoxine and dapsone in field isolates from Kenya: point mutations in dihydropteroate synthase may not be the only determinants in sulfa resistance.
We have determined the relationship between point mutations in the gene that encodes the sulfa target, dihydropteroate synthase… Expand
1999
1999
Stereoselective characterization of the 1,4-dihydropyridine binding site at L-type calcium channels in the resting state and the opened/inactivated state.
  • K. Schleifer
  • Journal of medicinal chemistry
  • 1999
    • Corpus ID: 21407750
Via a 3D-QSAR pseudoreceptor modeling approach, atomistic binding site models for pharmacologically active 1,4-dihydropyridines… Expand
1996
1996
Molecular cloning and functional expression of human deoxyhypusine synthase cDNA based on expressed sequence tag information.
Deoxyhypusine synthase is an NAD(+)-dependent enzyme that catalyses the formation of a deoxyhypusine residue on the eukaryotic… Expand
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Highly Cited
1995
Highly Cited
1995
Deoxyhypusine Synthase from Rat Testis: Purification and Characterization (*)
Deoxyhypusine synthase is the first enzyme involved in the post-translational formation of hypusine, a unique amino acid that… Expand
Highly Cited
1995
Highly Cited
1995
Calcium Binding in the Pore of L-type Calcium Channels Modulates High Affinity Dihydropyridine Binding (*)
The pore-forming α1 subunit of L-type voltage-gated Ca channels contains a Ca-binding site that is allosterically coupled to the… Expand
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