deoxyhypusine monooxygenase activity

Known as: DOHH activity, deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating), deoxyhypusine hydroxylase activity 
Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O… (More)

Topic mentions per year

Topic mentions per year

1986-2016
012319862016

Papers overview

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2016
2016
Replication of the human immunodeficiency virus type 1 (HIV-1) is dependent on eIF5A hypusination. Hypusine is formed post… (More)
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2014
2014
Although cells express hundreds of metalloenzymes, the mechanisms by which apoenzymes receive their metal cofactors are largely… (More)
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2012
2012
Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of an unusual amino acid hypusine… (More)
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2011
2011
Eukaryotic initiation factor 5A (eIF5A) has recently been identified as a biomarker of prognostic significance and therapeutic… (More)
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2009
2009
Eukaryotic translation initiation factor eIF5A has been implicated in HIV-1 replication. This protein contains the apparently… (More)
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2007
2007
Deoxyhypusine hydroxylase is the second of the two enzymes that catalyzes the maturation of eukaryotic initiation factor 5A… (More)
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2006
2006
Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of hypusine (N(epsilon)-(4-amino-2… (More)
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2006
2006
Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of hypusine (N -(4-amino-2… (More)
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1996
1996
Hypusine synthesis in the eukaryotic initiation factor 5A is a unique two-step posttranslational modification. After… (More)
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1989
1989
The inhibition of deoxyhypusine hydroxylase was studied in vitro. Of the polyamines tested, spermine and its homologue thermine… (More)
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