FAQ

deoxyhypusine monooxygenase activity

Known as: DOHH activity, deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating), deoxyhypusine hydroxylase activity 
Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O… (More)

Topic mentions per year

Topic mentions per year

1986-2016
012319862016

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1 relation
deoxyhypusine monooxygenase

Related mentions per year

Related mentions per year

1986-2018
19801990200020102020
deoxyhypusine monooxygenase activity
deoxyhypusine monooxygenase

Papers overview

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2016
2016
Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5'untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs.
Replication of the human immunodeficiency virus type 1 (HIV-1) is dependent on eIF5A hypusination. Hypusine is formed post… (More)
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2014
2014
Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase.
Although cells express hundreds of metalloenzymes, the mechanisms by which apoenzymes receive their metal cofactors are largely… (More)
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2012
2012
A Unique Modification of the Eukaryotic Initiation Factor 5A Shows the Presence of the Complete Hypusine Pathway in Leishmania donovani
Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of an unusual amino acid hypusine… (More)
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2011
2011
A rapid and robust assay for the determination of the amino acid hypusine as a possible biomarker for a high-throughput screening of antimalarials and for the diagnosis and therapy of different…
Eukaryotic initiation factor 5A (eIF5A) has recently been identified as a biomarker of prognostic significance and therapeutic… (More)
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2009
2009
Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A
Eukaryotic translation initiation factor eIF5A has been implicated in HIV-1 replication. This protein contains the apparently… (More)
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2007
2007
Molecular cloning and functional expression of bovine deoxyhypusine hydroxylase cDNA and homologs.
Deoxyhypusine hydroxylase is the second of the two enzymes that catalyzes the maturation of eukaryotic initiation factor 5A… (More)
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2006
2006
Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected].
Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of hypusine (N(epsilon)-(4-amino-2… (More)
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2006
2006
Deoxyhypusine Hydroxylase Is an Fe(II)-dependent, Heat-repeat Enzyme IDENTIFICATION OF AMINO ACID RESIDUES CRITICAL FOR Fe(II) BINDING AND CATALYSIS*â–¡
Deoxyhypusine hydroxylase (DOHH) catalyzes the final step in the post-translational synthesis of hypusine (N -(4-amino-2… (More)
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1996
1996
Evaluation of the metal ion requirement of the human deoxyhypusine hydroxylase from HeLa cells using a novel enzyme assay.
Hypusine synthesis in the eukaryotic initiation factor 5A is a unique two-step posttranslational modification. After… (More)
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1989
1989
Inhibition of deoxyhypusine hydroxylase by polyamines and by a deoxyhypusine peptide.
The inhibition of deoxyhypusine hydroxylase was studied in vitro. Of the polyamines tested, spermine and its homologue thermine… (More)
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