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deoxyhypusine monooxygenase activity

Known as: DOHH activity, deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating), deoxyhypusine hydroxylase activity 
Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O… Expand
National Institutes of Health

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deoxyhypusine monooxygenase

Papers overview

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2016
2016
Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5'untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs.
Replication of the human immunodeficiency virus type 1 (HIV-1) is dependent on eIF5A hypusination. Hypusine is formed post… Expand
2011
2011
Assay of deoxyhypusine hydroxylase activity.
The eukaryotic translation initiation factor 5A (eIF5A) is the only cellular protein that contains an unusual amino acid… Expand
2007
2007
Molecular cloning and functional expression of bovine deoxyhypusine hydroxylase cDNA and homologs.
Deoxyhypusine hydroxylase is the second of the two enzymes that catalyzes the maturation of eukaryotic initiation factor 5A… Expand
1989
1989
Inhibition of deoxyhypusine hydroxylase by polyamines and by a deoxyhypusine peptide.
The inhibition of deoxyhypusine hydroxylase was studied in vitro. Of the polyamines tested, spermine and its homologue thermine… Expand
1986
1986
Indirect assays for deoxyhypusine hydroxylase using dual-label ratio changes and oxidative release of radioactivity.
Two procedures for rapid assay of deoxyhypusine hydroxylase activity are described. One of these assays measures changes in the… Expand
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