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deltorphin

Known as: Tyr-Met-Phe-His-Leu-Met-Asp-NH2, dermenkephalin, tyrosyl-methionyl-phenylalanyl-histidyl-leucyl-methionyl-aspartamide 
National Institutes of Health

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Oligopeptides

Papers overview

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2009
2009
Modification of the Phe3 aromatic moiety in delta receptor-selective dermorphin/deltorphin-related tetrapeptides. Effects on opioid receptor binding.
The previously described cyclic delta opioid receptor-selective tetrapeptide H-Tyr-D-Cys-Phe-D-Pen-OH (JOM-13) was modified at… 
2009
2009
Substitution of aromatic and nonaromatic amino acids for the Phe3 residue in the delta-selective opioid peptide deltorphin I: effects on binding affinity and selectivity.
Deltorphins I and II (Tyr-D-Ala-Phe-Asp-Val-Val-Gly NH2 and Tyr-D-Ala-Phe-Glu-Val-Val-Gly NH2) display a high degree of delta… 
2003
2003
Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist.
A number of novel alpha-melanotropin (alpha-MSH) analogues have been designed, synthesized, and assayed for bioactivity at the… 
2000
2000
Enhanced contractile responsiveness to cytosolic Ca(2+) by delta-2 opioid agonist deltorphin in intact guinea pig hearts.
Opioid receptor subtypes, delta and kappa, are found in cardiac tissue and may play a role in cardiac function. We explored if… 
1997
1997
Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3.
Two approaches to the design of very active and highly selective delta opioid peptides were used to obtain new deltorpin analogs… 
1994
1994
Ultrastructural study of delta-opioid receptors in the dorsal horn of the rat spinal cord using monoclonal anti-idiotypic antibodies.
The ultrastructural localization of delta-opioid receptors was studied using monoclonal anti-idiotypic antibody prepared with an… 
1993
1993
Quantitative two‐dimensional nmr study of dermenkephalin, a highly potent and selective δ‐opioid peptide
Dermenkephalin, H‐Tyr‐(D) Met‐Phe‐His‐Leu‐Met‐Asp‐NH2, a highly potent and selective δ‐opioid peptide isolated from frog skin… 
1992
1992
Conformationally restricted deltorphin analogues.
Conformationally restricted deltorphin analogues were synthesized either through incorporation of cyclic phenylalanine analogues… 
1992
1992
Solution structure of deltorphin I at 265 K: a quantitative NMR study.
Deltorphin I, a delta-selective opioid peptide, has been studied in a DMSOd6/H2O cryoprotective mixture by two-dimensional (2D… 
1991
1991
Opioid activity of dermenkephalin analogues in the guinea‐pig myenteric plexus and the hamster vas deferens
1 To elucidate the structural features required for selective and potent action of dermenkephalin at the δ‐opioid receptor, a… 
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