definitive erythrocyte differentiation

Known as: definitive RBC differentiation, definitive erythropoiesis, definitive red blood cell differentiation 
Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis. [GOC:add, GOC:BHF, GOC:dph]
National Institutes of Health

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Broader (1)

definitive hemopoiesis
regulation of definitive erythrocyte differentiation

Papers overview

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Review
2014
Review
2014
Primitive and definitive erythropoiesis in mammals
Red blood cells (RBCs), which constitute the most abundant cell type in the body, come in two distinct flavors- primitive and… (More)
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Highly Cited
2006
Highly Cited
2006
A global role for EKLF in definitive and primitive erythropoiesis.
Erythroid Kruppel-like factor (EKLF, KLF1) plays an important role in definitive erythropoiesis and beta-globin gene regulation… (More)
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Highly Cited
2004
Highly Cited
2004
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages
In mammals, the fetal liver is the first site of definitive erythropoiesis—the generation of mature, enucleated red cells. The… (More)
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Highly Cited
2004
Highly Cited
2004
Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis.
The initial steps of primitive hematopoiesis and endothelial vascular formation in the human embryo remain to be defined. Here… (More)
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Highly Cited
2001
Highly Cited
2001
Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver.
Mature erythrocytes in mammals have no nuclei, although they differentiate from nucleated precursor cells. The mechanism by which… (More)
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Highly Cited
1998
Highly Cited
1998
Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
A variety of cytokines activate receptor-associated members of the Janus family of protein tyrosine kinases (Jaks). To assess the… (More)
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Highly Cited
1998
Highly Cited
1998
Jak2 Deficiency Defines an EssentialDevelopmental Checkpoint in DefinitiveHematopoiesis
Janus kinases (Jaks) play an important role in signal transduction via cytokine and growth factor receptors. A targeted… (More)
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Highly Cited
1997
Highly Cited
1997
Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development.
We investigated the function of Lhx2, a LIM homeobox gene expressed in developing B-cells, forebrain and neural retina, by… (More)
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Highly Cited
1996
Highly Cited
1996
Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.
Although the hormone erythropoietin (Epo) and its receptor (EpoR) are known to play important roles in the regulation of… (More)
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Highly Cited
1995
Highly Cited
1995
Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
Erythropoietin (EPO) is the principal growth factor regulating the production of circulating erythrocytes. We introduced null… (More)
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