dapivirine

Known as: 4-[[4-[(2,4,6-trimethylphenyl)amino]-2-pyrimidinyl]amino] benzonitrile, TMC120, TMC120-R147681 
A diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Dapivirine has activity against wild-type virus strains and strains harboring… (More)
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
  • The New England journal of medicine
  • 2016
BACKGROUND Antiretroviral medications that are used as prophylaxis can prevent acquisition of human immunodeficiency virus type 1… (More)
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2014
2014
The HIV-1 replication inhibitor dapivirine (DPV) is one of the most promising drug candidates being used in topical microbicide… (More)
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2014
2014
OBJECTIVES Women-initiated HIV-prevention products are urgently needed. To address this need, a trial was conducted to assess the… (More)
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2012
2012
Antiretroviral-based microbicides may offer a means to reduce the sexual transmission of HIV-1. Suboptimal use of a microbicide… (More)
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2011
2011
OBJECTIVE To evaluate the candidate antiretroviral microbicide compounds, dapivirine (DAP) and tenofovir (TFV), alone and in… (More)
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Highly Cited
2010
Highly Cited
2010
Dual segment polyurethane intravaginal rings (IVRs) were fabricated to enable sustained release of antiretroviral agents… (More)
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2010
2010
UNLABELLED To assess the pharmacokinetics of dapivirine in plasma and dapivirine concentrations in cervicovaginal fluids (CVF… (More)
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Highly Cited
2009
Highly Cited
2009
Vaginal delivery of 200 mg or 25 mg dapivirine from intravaginal rings (IVRs) was evaluated over a 7-day period in two phase 1… (More)
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2008
2008
Women-controlled methods for prevention of male-to-female sexual transmission of HIV-1 are urgently needed. Providing inhibitory… (More)
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2008
2008
Dapivirine is a nonnucleoside reverse transcriptase inhibitor being developed as a topical microbicide for the prevention of… (More)
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