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daniplestim

A synthetic cytokine and interleukin-3 (IL-3) receptor agonist with enhanced hematopoietic potency. Daniplestim exhibits 10- to 20-fold greater… Expand
National Institutes of Health

Related topics

Related topics

6 relations
Inhibition of Cell ProliferationInterleukin-3 Receptoranalogs & derivatives

Broader (2)

Interleukin-3Peptide Fragments

Narrower (1)

SC 55494

Papers overview

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2011
2011
Iontophoresis of a 13 kDa protein monitored by subcutaneous microdialysis in vivo.
BACKGROUND The purpose of this study was to optimize parameters pertaining to microdialysis technique so as to make this method… Expand
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2010
2010
Transdermal delivery of a ~13 kDa protein—an in vivo comparison of physical enhancement methods
The availability of several enhancement techniques has made it possible to study delivery of macromolecules through skin. This… Expand
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2009
2009
Molecular charge mediated transport of a 13 kD protein across microporated skin.
Transport of proteins across the skin is highly limited owing to their hydrophilic nature and large molecular size. This study… Expand
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2001
2001
Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells
Modified and chimeric cytokines have been developed to aid in the recovery of hematopoietic precursor cells after myeloablative… Expand
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2000
2000
Mobilization of peripheral-blood stem cells by concurrent administration of daniplestim and granulocyte colony-stimulating factor in patients with breast cancer or lymphoma.
PURPOSE To evaluate the safety and hematopoietic activity of daniplestim administered concurrently with granulocyte colony… Expand
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2000
2000
Effective ex vivo generation of granulopoietic postprogenitor cells from mobilized peripheral blood CD34(+) cells.
OBJECTIVE Neutropenia following high-dose chemotherapy and peripheral blood progenitor cell (PBPC) transplantation might be… Expand
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1999
1999
Administration of daniplestim and granulocyte colony-stimulating factor for the mobilization of hematopoietic progenitor cells in nonhuman primates.
We investigated the effects of administering a high-affinity interleukin-3 receptor agonist (daniplestim) and granulocyte colony… Expand
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1999
1999
Myelopoietin, a chimeric agonist of human interleukin 3 and granulocyte colony-stimulating factor receptors, mobilizes CD34+ cells that rapidly engraft lethally x-irradiated nonhuman primates.
Myelopoietin (MPO), a multifunctional agonist of interleukin 3 and granulocyte colony-stimulating factor (G-CSF) receptors, was… Expand
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1999
1999
Evaluation of refolding conditions for a recombinant human interleukin-3 variant (daniplestim).
The refolding of daniplestim, a human interleukin-3 variant (SC-55494) from Escherichia coli inclusion bodies, was optimized… Expand
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1998
1998
The combined administration of daniplestim and Mpl ligand augments the hematopoietic reconstitution observed with single cytokine administration in a nonhuman primate model of myelosuppression.
This study evaluated the ability of daniplestim, a high affinity interleukin 3 receptor agonist, to enhance the hematopoietic… Expand
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