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daniplestim

A synthetic cytokine and interleukin-3 (IL-3) receptor agonist with enhanced hematopoietic potency. Daniplestim exhibits 10- to 20-fold greater… Expand
National Institutes of Health

Related topics

Related topics

6 relations
Inhibition of Cell ProliferationInterleukin-3 Receptoranalogs & derivatives

Broader (2)

Interleukin-3Peptide Fragments

Narrower (1)

SC 55494

Papers overview

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2010
2010
Transdermal delivery of a ~13 kDa protein—an in vivo comparison of physical enhancement methods
The availability of several enhancement techniques has made it possible to study delivery of macromolecules through skin. This… Expand
2009
2009
Molecular charge mediated transport of a 13 kD protein across microporated skin.
Transport of proteins across the skin is highly limited owing to their hydrophilic nature and large molecular size. This study… Expand
2001
2001
Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells
Modified and chimeric cytokines have been developed to aid in the recovery of hematopoietic precursor cells after myeloablative… Expand
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2000
2000
Mobilization of peripheral-blood stem cells by concurrent administration of daniplestim and granulocyte colony-stimulating factor in patients with breast cancer or lymphoma.
PURPOSE To evaluate the safety and hematopoietic activity of daniplestim administered concurrently with granulocyte colony… Expand
2000
2000
Effective ex vivo generation of granulopoietic postprogenitor cells from mobilized peripheral blood CD34(+) cells.
OBJECTIVE Neutropenia following high-dose chemotherapy and peripheral blood progenitor cell (PBPC) transplantation might be… Expand
2000
2000
Clinical-scale production of granulocyte progenitor and post-progenitor cells using daniplestim, leridistim, Progenipoietin, Promegapoietin and autologous plasma.
BACKGROUND Supplementation of PBPC autografts with ex vivo expanded PBMC may significantly reduce or eliminate the period of… Expand
1999
1999
Administration of daniplestim and granulocyte colony-stimulating factor for the mobilization of hematopoietic progenitor cells in nonhuman primates.
We investigated the effects of administering a high-affinity interleukin-3 receptor agonist (daniplestim) and granulocyte colony… Expand
1999
1999
Myelopoietin, a chimeric agonist of human interleukin 3 and granulocyte colony-stimulating factor receptors, mobilizes CD34+ cells that rapidly engraft lethally x-irradiated nonhuman primates.
Myelopoietin (MPO), a multifunctional agonist of interleukin 3 and granulocyte colony-stimulating factor (G-CSF) receptors, was… Expand
1999
1999
Evaluation of refolding conditions for a recombinant human interleukin‐3 variant (daniplestim)
The refolding of daniplestim, a human interleukin‐3 variant (SC‐55494) from Escherichia coli inclusion bodies, was optimized… Expand
1998
1998
The combined administration of daniplestim and mpl ligand augments the hematopoietic reconstitution observed with single cytokine administration in a nonhuman primate model of myelosuppression
This study evaluated the ability of daniplestim, a high affinity interleukin 3 receptor agonist, to enhance the hematopoietic… Expand
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