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dGTPase

Deoxyguanosine triphosphate (dGTP) triphosphohydrolase (EC 3.1.5.1). Highly specific for dGTP, producing deoxyguanosine and inorganic… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (1)

Alkaline Phosphatase
Enzyme GeneEsterase GeneHydrolaseHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate.
2001
2001
Analysis of MTH1 gene function in mice with targeted mutagenesis.
2001
2001
8-Oxo-dGTPase, Which Prevents Oxidative Stress-Induced DNA Damage, Increases in the Mitochondria From Failing Hearts
Background— Reactive oxygen species (ROS) can cause an oxidative modification of nucleotides, such as 8-oxo-7,8… 
2000
2000
Induction of 8-oxo-dGTPase activity in human lymphoid cells and normal fibroblasts by oxidative stress.
1999
1999
Higher activity of 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) coincides with lower background levels of 8-oxo-2'-deoxyguanosine in DNA of fetal compared with…
Highly Cited
1995
Highly Cited
1995
cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides.
The enzyme, 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase (8-oxo-dGTPase), is present in various organisms and plays an… 
Highly Cited
1995
Highly Cited
1995
Mouse MTH1 Protein with 8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-Triphosphatase Activity That Prevents Transversion Mutation
8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal… 
1995
1995
Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpoliposis colorectal cancer.
The human MTH1 gene, a homolog of the E. coli mutator gene mutT, encodes 8-oxo-dGTPase that degrades a mutagenic substrate for… 
1995
1995
Cell type-specific expression of human 8-oxo-7,8-dihydroguanosine triphosphatase in normal breast and skin tissues in vivo.
8-Oxo-7,8-dihydroguanosine triphosphate (8-oxo-dGTP) is formed from the oxidation of GTP in the nucleotide pools of cells during… 
1993
1993
DNA binding properties of the deoxyguanosine triphosphate triphosphohydrolase of Escherichia coli.
The dgt gene of Escherichia coli encodes a deoxyguanosine triphosphate triphosphohydrolase (dGTPase) that hydrolyzes dGTP to… 
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