cytochrome P-450 CYP121

Known as: CYP121, CYP450 MT2 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2017
02420022017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
The essential enzyme CYP121 is a target for drug development against antibiotic resistant strains of Mycobacterium tuberculosis… (More)
Is this relevant?
2013
2013
Cytochrome P450 CYP121 is essential for the viability of Mycobacterium tuberculosis. Studies in vitro show that it can use the… (More)
Is this relevant?
2012
2012
The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) drives a critical need for new front-line tuberculosis (TB… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2009
2009
The gene encoding the cytochrome P450 CYP121 is essential for Mycobacterium tuberculosis. However, the CYP121 catalytic activity… (More)
  • figure 1
  • figure 3
  • figure 2
  • figure 4
  • figure 5
Is this relevant?
2008
2008
Mycobacterium tuberculosis (Mtb) cytochrome P450 gene CYP121 is shown to be essential for viability of the bacterium in vitro by… (More)
Is this relevant?
2007
2007
We demonstrate that photoexcitation of NAD(P)H reduces heme iron of Mycobacterium tuberculosis P450s CYP121 and CYP51B1 on the… (More)
Is this relevant?
2006
2006
Azole and triazole drugs are cytochrome P450 inhibitors widely used as fungal antibiotics and possessing potent antimycobacterial… (More)
Is this relevant?
2003
2003
The first structure of a P450 to an atomic resolution of 1.06 A has been solved for CYP121 from Mycobacterium tuberculosis. A… (More)
  • table I
  • table II
  • figure 2
  • figure 3
  • figure 1
Is this relevant?
2002
2002
The genome sequence of Mycobacterium tuberculosis has revealed the presence of 20 different cytochrome P450 mono-oxygenases… (More)
Is this relevant?
2002
2002
The CYP121 gene from the pathogenic bacterium Mycobacterium tuberculosis has been cloned and expressed in Escherichia coli, and… (More)
Is this relevant?