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cytochrome P-450 CYP121

Known as: CYP121, CYP450 MT2 
 
National Institutes of Health

Papers overview

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2014
2014
Among 20 p450s of Mycobacterium tuberculosis (Mt), CYP121 has received an outstanding interest, not only due to its essentiality… Expand
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2013
2013
Freedom to merge: A combination of crystal structure examination and in silico predictions made it possible to overcome the… Expand
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2012
2012
The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) drives a critical need for new front-line tuberculosis (TB… Expand
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Highly Cited
2009
Highly Cited
2009
The gene encoding the cytochrome P450 CYP121 is essential for Mycobacterium tuberculosis. However, the CYP121 catalytic activity… Expand
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2008
2008
Mycobacterium tuberculosis (Mtb) cytochrome P450 gene CYP121 is shown to be essential for viability of the bacterium in vitro by… Expand
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2008
2008
CYP130 is one of the 20 Mycobacterium tuberculosis cytochrome P450 enzymes, only two of which, CYP51 and CYP121, have so far been… Expand
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2007
2007
We demonstrate that photoexcitation of NAD(P)H reduces heme iron of Mycobacterium tuberculosis P450s CYP121 and CYP51B1 on the… Expand
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2003
2003
The first structure of a P450 to an atomic resolution of 1.06 A has been solved for CYP121 from Mycobacterium tuberculosis. A… Expand
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2002
2002
The CYP121 gene from the pathogenic bacterium Mycobacterium tuberculosis has been cloned and expressed in Escherichia coli, and… Expand
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2002
2002
The genome sequence of Mycobacterium tuberculosis has revealed the presence of 20 different cytochrome P450 mono-oxygenases… Expand
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