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cytochrome P-450 CYP121

Known as: CYP121, CYP450 MT2 
 
National Institutes of Health

Papers overview

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2015
2015
A new library of phenothiazine and 1,3,4-thiadiazole hybrid derivatives (5a-u) was designed based on the molecular hybridization… Expand
2013
2013
Background: Little is known about the substrate specificity of the essential P450 CYP121 from Mycobacterium tuberculosis. Results… Expand
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Highly Cited
2012
Highly Cited
2012
The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) drives a critical need for new front-line tuberculosis (TB… Expand
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Highly Cited
2009
Highly Cited
2009
The gene encoding the cytochrome P450 CYP121 is essential for Mycobacterium tuberculosis. However, the CYP121 catalytic activity… Expand
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Highly Cited
2008
Highly Cited
2008
Mycobacterium tuberculosis (Mtb) cytochrome P450 gene CYP121 is shown to be essential for viability of the bacterium in vitro by… Expand
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Highly Cited
2008
Highly Cited
2008
CYP130 is one of the 20 Mycobacterium tuberculosis cytochrome P450 enzymes, only two of which, CYP51 and CYP121, have so far been… Expand
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Highly Cited
2007
Highly Cited
2007
We demonstrate that photoexcitation of NAD(P)H reduces heme iron of Mycobacterium tuberculosis P450s CYP121 and CYP51B1 on the… Expand
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Highly Cited
2003
Highly Cited
2003
The first structure of a P450 to an atomic resolution of 1.06 Å has been solved for CYP121 fromMycobacterium tuberculosis. A… Expand
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Highly Cited
2002
Highly Cited
2002
The CYP121 gene from the pathogenic bacterium Mycobacterium tuberculosis has been cloned and expressed in Escherichia coli, and… Expand
Highly Cited
2002
Highly Cited
2002
The genome sequence of Mycobacterium tuberculosis has revealed the presence of 20 different cytochrome P450 mono-oxygenases… Expand
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