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cytochrome P-450 CYP121
Known as:
CYP121
, CYP450 MT2
National Institutes of Health
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Related topics
1 relation
Broader (1)
Cytochrome P450
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Molecular hybridization approach for phenothiazine incorporated 1,2,3-triazole hybrids as promising antimicrobial agents: Design, synthesis, molecular docking and in silico ADME studies.
Rajkumar Reddyrajula
,
Udayakumar Dalimba
,
S. Madan Kumar
European journal of medicinal chemistry
2019
Corpus ID: 73473886
2015
2015
Design of new phenothiazine-thiadiazole hybrids via molecular hybridization approach for the development of potent antitubercular agents.
J. Ramprasad
,
N. Nayak
,
Udayakumar Dalimba
European journal of medicinal chemistry
2015
Corpus ID: 33172163
Highly Cited
2012
Highly Cited
2012
Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121.
S. Hudson
,
K. J. McLean
,
+5 authors
C. Abell
Angewandte Chemie
2012
Corpus ID: 34266393
The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) drives a critical need for new front-line tuberculosis (TB…
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Highly Cited
2009
Highly Cited
2009
Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis
P. Belin
,
M. Le Du
,
+11 authors
M. Gondry
Proceedings of the National Academy of Sciences
2009
Corpus ID: 24323868
The gene encoding the cytochrome P450 CYP121 is essential for Mycobacterium tuberculosis. However, the CYP121 catalytic activity…
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Highly Cited
2008
Highly Cited
2008
Characterization of Active Site Structure in CYP121
K. J. McLean
,
P. Carroll
,
+12 authors
A. Munro
Journal of Biological Chemistry
2008
Corpus ID: 21253171
Mycobacterium tuberculosis (Mtb) cytochrome P450 gene CYP121 is shown to be essential for viability of the bacterium in vitro by…
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Highly Cited
2008
Highly Cited
2008
Mycobacterium tuberculosis CYP130
H. Ouellet
,
L. Podust
,
P. D. de Montellano
Journal of Biological Chemistry
2008
Corpus ID: 25909033
CYP130 is one of the 20 Mycobacterium tuberculosis cytochrome P450 enzymes, only two of which, CYP51 and CYP121, have so far been…
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Highly Cited
2007
Highly Cited
2007
Rapid P450 Heme Iron Reduction by Laser Photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1
A. J. Dunford
,
K. J. McLean
,
+4 authors
A. Munro
Journal of Biological Chemistry
2007
Corpus ID: 13732136
We demonstrate that photoexcitation of NAD(P)H reduces heme iron of Mycobacterium tuberculosis P450s CYP121 and CYP51B1 on the…
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Highly Cited
2003
Highly Cited
2003
Atomic Structure of Mycobacterium tuberculosis CYP121 to 1.06 Å Reveals Novel Features of Cytochrome P450*
D. Leys
,
C. Mowat
,
+4 authors
A. Munro
The Journal of Biological Chemistry
2003
Corpus ID: 12308915
The first structure of a P450 to an atomic resolution of 1.06 Å has been solved for CYP121 fromMycobacterium tuberculosis. A…
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Highly Cited
2002
Highly Cited
2002
Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.
K. J. McLean
,
K. R. Marshall
,
+6 authors
A. Munro
Microbiology
2002
Corpus ID: 22712862
The genome sequence of Mycobacterium tuberculosis has revealed the presence of 20 different cytochrome P450 mono-oxygenases…
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Highly Cited
2002
Highly Cited
2002
Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis.
K. J. McLean
,
M. Cheesman
,
+9 authors
A. Munro
Journal of inorganic biochemistry
2002
Corpus ID: 22013920
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