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Protein activity is often regulated by altering the oligomerization state. One mechanism of multimerization involves domain… Expand The ratio between proteases and their inhibitors is unbalanced in cancer. The cysteine protease inhibitor cystatin C is… Expand The asparaginyl endopeptidase legumain and its inhibitor cystatin E/M are endogenously glycosylated. However, little is known… Expand ABSTRACT We and others have shown that the cystatin E/M gene is inactivated in primary human tumors, pointing to its role as a… Expand TBX2 is an oncogenic transcription factor known to drive breast cancer proliferation. We have identified the cysteine protease… Expand Legumain, an asparaginyl endopeptidase, is up-regulated in tumour and tumour-associated cells, and is linked to the processing of… Expand BackgroundHigh activity of cysteine proteases such as legumain and the cathepsins have been shown to facilitate growth and… Expand DNA hypermethylation-mediated gene silencing is a frequent and early contributor to aberrant cell growth and invasion in cancer… Expand We have previously localized a cervical cancer tumor suppressor gene to a 300 kb interval of 11q13. Analysis of candidate genes… Expand A novel human cystatin gene was identified in a differential display comparison aimed at the isolation of transcriptionally… Expand