cystathionine beta-synthase activity

Known as: serine sulfhydrase activity, methylcysteine synthase activity, beta-thionase activity 
Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. [EC:4.2.1.22]
National Institutes of Health

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Cystathionine beta-Synthasenegative regulation of cystathionine beta-synthase activity

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2008
2008
Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations.
Human cystathionine beta-synthase (CBS) catalyzes a pyridoxal 5'-phosphate (PLP) dependent beta-replacement reaction to… (More)
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2005
2005
Inhibitory effect of copper on cystathionine beta-synthase activity: protective effect of an analog of the human albumin N-terminus.
Copper was added to truncated, recombinant cystathionine beta-synthase (CBS), and the enzyme activity was assessed by measuring… (More)
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Highly Cited
1998
Highly Cited
1998
Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity.
Human cystathionine beta-synthase catalyzes the first step in the catabolic removal of the toxic metabolite, homocysteine. It is… (More)
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1996
1996
The effect of a high-protein diet on cystathionine beta-synthase activity and its transcript levels in rat liver.
Hepatic cystathionine beta-synthase activity was increased in rats fed a high-protein diet for three or five days as compared to… (More)
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1995
1995
Effect of cysteine on expression of cystathionine beta-synthase in the rat liver.
Hepatic cystathionine beta-synthase activity is decreased by the addition of cysteine to the diet. This effect of cysteine was… (More)
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Highly Cited
1994
Highly Cited
1994
Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism.
In a recent hypothesis [Selhub and Miller (1992) Am. J. Clin. Nutr. 55, 131-138], we proposed that homocysteinaemia arises from… (More)
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1991
1991
Regulation of Sulfate Assimilation by Light and O-Acetyl-l-Serine in Lemna minor L.
The effect of 0.5 millimolar O-acetyl-l-serine added to the nutrient solution on sulfate assimilation of Lemna minor L… (More)
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1989
1989
Localization of enzymes of assimilatory sulfate reduction in pea roots
The localization of enzymes of assimilatory sulfate reduction was examined in roots of 5-d-old pea (Pisum sativum L.) seedlings… (More)
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1980
1980
Affinity of cystathionine beta-synthase for pyridoxal 5'-phosphate in cultured cells. A mechanism for pyridoxine-responsive homocystinuria.
Previous attempts to correlate in vivo pyridoxine-responsiveness with in vitro assays of cystathionine beta-synthase activity in… (More)
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1978
1978
Homocystinuria. Evidence for three distinct classes of cystathionine beta-synthase mutants in cultured fibroblasts.
We have compared in vivo pyridoxine responsiveness with in vitro cystathionine beta-synthase activity in extracts of confluent… (More)
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