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cystathionine beta-synthase activity

Known as: serine sulfhydrase activity, methylcysteine synthase activity, beta-thionase activity 
Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. [EC:4.2.1.22]
National Institutes of Health

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Cystathionine beta-Synthasenegative regulation of cystathionine beta-synthase activity

Papers overview

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Highly Cited
2006
Highly Cited
2006
Suppression of Methionine-Induced Hyperhomocysteinemia by Glycine and Serine in Rats
The hyperhomocysteinemia induced by a dietary addition of 1% methionine was significantly suppressed by the concurrent addition… 
2004
2004
The essentiality of sulfur is closely related to nitrogen metabolism: a clue to hyperhomocysteinaemia
Abstract N and S metabolisms are closely interwoven throughout both the plant and animal kingdoms. The essentiality of S relates… 
Highly Cited
1998
Highly Cited
1998
Evidence for Heme-mediated Redox Regulation of Human Cystathionine β-Synthase Activity*
Human cystathionine β-synthase catalyzes the first step in the catabolic removal of the toxic metabolite, homocysteine. It is… 
Highly Cited
1994
Highly Cited
1994
Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism.
In a recent hypothesis [Selhub and Miller (1992) Am. J. Clin. Nutr. 55, 131-138], we proposed that homocysteinaemia arises from… 
Highly Cited
1993
Highly Cited
1993
Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology.
Mild homocysteinemia occurs surprisingly often in patients with premature vascular disease. We studied the possible enzymatic… 
Highly Cited
1992
Highly Cited
1992
Homocysteine catabolism: levels of 3 enzymes in cultured human vascular endothelium and their relevance to vascular disease.
Highly Cited
1991
Highly Cited
1991
Regulation of Sulfate Assimilation by Light and O-Acetyl-l-Serine in Lemna minor L.
The effect of 0.5 millimolar O-acetyl-l-serine added to the nutrient solution on sulfate assimilation of Lemna minor L… 
1980
1980
Affinity of cystathionine beta-synthase for pyridoxal 5'-phosphate in cultured cells. A mechanism for pyridoxine-responsive homocystinuria.
Previous attempts to correlate in vivo pyridoxine-responsiveness with in vitro assays of cystathionine beta-synthase activity in… 
Highly Cited
1978
Highly Cited
1978
Homocystinuria. Evidence for three distinct classes of cystathionine beta-synthase mutants in cultured fibroblasts.
We have compared in vivo pyridoxine responsiveness with in vitro cystathionine beta-synthase activity in extracts of confluent… 
Highly Cited
1972
Highly Cited
1972
Studies of l-Cysteine Biosynthetic Enzymes in Phaseolus vulgaris L.
In higher plants the biosynthesis of l-cysteine from l-serine, acetylCoA, and sulfide requires serine transacetylase and O… 
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