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cystathionine beta-synthase activity

Known as: serine sulfhydrase activity, methylcysteine synthase activity, beta-thionase activity 
Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. [EC:4.2.1.22]
National Institutes of Health

Related topics

Related topics

2 relations
Cystathionine beta-Synthasenegative regulation of cystathionine beta-synthase activity

Papers overview

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2006
2006
Suppression of Methionine-Induced Hyperhomocysteinemia by Glycine and Serine in Rats
The hyperhomocysteinemia induced by a dietary addition of 1% methionine was significantly suppressed by the concurrent addition… 
2004
2004
The essentiality of sulfur is closely related to nitrogen metabolism: a clue to hyperhomocysteinaemia
Abstract N and S metabolisms are closely interwoven throughout both the plant and animal kingdoms. The essentiality of S relates… 
2004
2004
Localization of enzymes of assimilatory sulfate reduction in pea roots
The localization of enzymes of assimilatory sulfate reduction was examined in roots of 5-d-old pea (Pisum sativum L.) seedlings… 
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Highly Cited
1998
Highly Cited
1998
Evidence for Heme-mediated Redox Regulation of Human Cystathionine β-Synthase Activity*
Human cystathionine β-synthase catalyzes the first step in the catabolic removal of the toxic metabolite, homocysteine. It is… 
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Highly Cited
1994
Highly Cited
1994
Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism.
In a recent hypothesis [Selhub and Miller (1992) Am. J. Clin. Nutr. 55, 131-138], we proposed that homocysteinaemia arises from… 
Highly Cited
1993
Highly Cited
1993
Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology.
Mild homocysteinemia occurs surprisingly often in patients with premature vascular disease. We studied the possible enzymatic… 
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Highly Cited
1991
Highly Cited
1991
Regulation of Sulfate Assimilation by Light and O-Acetyl-l-Serine in Lemna minor L.
The effect of 0.5 millimolar O-acetyl-l-serine added to the nutrient solution on sulfate assimilation of Lemna minor L… 
1980
1980
Affinity of cystathionine beta-synthase for pyridoxal 5'-phosphate in cultured cells. A mechanism for pyridoxine-responsive homocystinuria.
Previous attempts to correlate in vivo pyridoxine-responsiveness with in vitro assays of cystathionine beta-synthase activity in… 
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Highly Cited
1978
Highly Cited
1978
Homocystinuria. Evidence for three distinct classes of cystathionine beta-synthase mutants in cultured fibroblasts.
We have compared in vivo pyridoxine responsiveness with in vitro cystathionine beta-synthase activity in extracts of confluent… 
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Highly Cited
1972
Highly Cited
1972
Studies of l-Cysteine Biosynthetic Enzymes in Phaseolus vulgaris L.
In higher plants the biosynthesis of l-cysteine from l-serine, acetylCoA, and sulfide requires serine transacetylase and O… 
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