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cystathionine beta-synthase activity
Known as:
serine sulfhydrase activity
, methylcysteine synthase activity
, beta-thionase activity
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Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. [EC:4.2.1.22]
National Institutes of Health
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Related topics
Related topics
2 relations
Cystathionine beta-Synthase
negative regulation of cystathionine beta-synthase activity
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Suppression of Methionine-Induced Hyperhomocysteinemia by Glycine and Serine in Rats
Shin-ichiro Fukada
,
Y. Shimada
,
T. Morita
,
K. Sugiyama
Bioscience, biotechnology and biochemistry
2006
Corpus ID: 18275208
The hyperhomocysteinemia induced by a dietary addition of 1% methionine was significantly suppressed by the concurrent addition…
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2004
2004
The essentiality of sulfur is closely related to nitrogen metabolism: a clue to hyperhomocysteinaemia
Y. Ingenbleek
,
V. Young
Nutrition research reviews
2004
Corpus ID: 3507765
Abstract N and S metabolisms are closely interwoven throughout both the plant and animal kingdoms. The essentiality of S relates…
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Highly Cited
1998
Highly Cited
1998
Evidence for Heme-mediated Redox Regulation of Human Cystathionine β-Synthase Activity*
S. Taoka
,
Sunil Ohja
,
X. Shan
,
W. Kruger
,
R. Banerjee
Journal of Biological Chemistry
1998
Corpus ID: 39790237
Human cystathionine β-synthase catalyzes the first step in the catabolic removal of the toxic metabolite, homocysteine. It is…
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Highly Cited
1994
Highly Cited
1994
Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism.
J. Miller
,
M. Nadeau
,
J. Smith
,
D. Smith
,
J. Selhub
Biochemical Journal
1994
Corpus ID: 40174709
In a recent hypothesis [Selhub and Miller (1992) Am. J. Clin. Nutr. 55, 131-138], we proposed that homocysteinaemia arises from…
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Highly Cited
1993
Highly Cited
1993
Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology.
N. Dudman
,
D. Wilcken
,
J. Wang
,
J. Lynch
,
D. Macey
,
P. Lundberg
Arteriosclerosis and Thrombosis A Journal of…
1993
Corpus ID: 7312127
Mild homocysteinemia occurs surprisingly often in patients with premature vascular disease. We studied the possible enzymatic…
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Highly Cited
1992
Highly Cited
1992
Homocysteine catabolism: levels of 3 enzymes in cultured human vascular endothelium and their relevance to vascular disease.
J. Wang
,
N. Dudman
,
D. Wilcken
,
J. Lynch
Atherosclerosis
1992
Corpus ID: 2567392
Highly Cited
1991
Highly Cited
1991
Regulation of Sulfate Assimilation by Light and O-Acetyl-l-Serine in Lemna minor L.
U. Neuenschwander
,
M. Suter
,
C. Brunold
Plant Physiology
1991
Corpus ID: 9031185
The effect of 0.5 millimolar O-acetyl-l-serine added to the nutrient solution on sulfate assimilation of Lemna minor L…
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1980
1980
Affinity of cystathionine beta-synthase for pyridoxal 5'-phosphate in cultured cells. A mechanism for pyridoxine-responsive homocystinuria.
M. Lipson
,
J. Kraus
,
L. Rosenberg
Journal of Clinical Investigation
1980
Corpus ID: 46185949
Previous attempts to correlate in vivo pyridoxine-responsiveness with in vitro assays of cystathionine beta-synthase activity in…
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Highly Cited
1978
Highly Cited
1978
Homocystinuria. Evidence for three distinct classes of cystathionine beta-synthase mutants in cultured fibroblasts.
B. Fowler
,
J. Kraus
,
S. Packman
,
L. Rosenberg
Journal of Clinical Investigation
1978
Corpus ID: 9958451
We have compared in vivo pyridoxine responsiveness with in vitro cystathionine beta-synthase activity in extracts of confluent…
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Highly Cited
1972
Highly Cited
1972
Studies of l-Cysteine Biosynthetic Enzymes in Phaseolus vulgaris L.
I. K. Smith
Plant Physiology
1972
Corpus ID: 33795823
In higher plants the biosynthesis of l-cysteine from l-serine, acetylCoA, and sulfide requires serine transacetylase and O…
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