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cyclothialidine

Known as: L-Alanine, N-(S-((2-carboxy-4,6-dihydroxy-3-methylphenyl)methyl)-N-(N-(cis-3-hydroxy-1-L-seryl-L-prolyl)-L-seryl)-L-cysteinyl)-, kappa-lactone 
 
National Institutes of Health

Papers overview

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2011
2011
The DNA gyrase inhibitor cyclothialidine had been shown to be a valuable lead structure for the discovery of new antibacterial… Expand
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2004
2004
Cyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensis NR0484 and is a… Expand
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1999
1999
DNA gyrase is the target of a number of antibacterial agents, including the coumarins and the cyclothialidines. To extend our… Expand
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Review
1998
Review
1998
Topoisomerases are ubiquitous enzymes necessary for controlling the interlinking and twisting of DNA molecules. Among the four… Expand
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1997
1997
Coumarin antibiotics, such as clorobiocin, novobiocin, and coumermycin A1, inhibit the supercoiling activity of gyrase by binding… Expand
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Highly Cited
1996
Highly Cited
1996
This study describes the first crystal structures of a complex between a DNA topoisomerase and a drug. We present the structures… Expand
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1996
1996
The sequence of the gyrase B subunit gene from Staphylococcus aureus strains resistant to the gyrase B subunit inhibitors… Expand
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1994
1994
We investigated how cyclothialidine (Ro 09-1437), a novel DNA gyrase inhibitor belonging to a new chemical class of compounds… Expand
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1993
1993
Cyclothialidine is a new DNA gyrase inhibitor isolated from Streptomyces filipinensis NR0484. Structurally, it belongs to a new… Expand
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Review
1993
Review
1993
Cyclothialidine is a new, potent DNA gyrase inhibitor isolated from Streptomyces filipinensis. However, it exhibits hardly any… Expand
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