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cyclosporin A synthetase

Known as: cyclosporin synthetase 
National Institutes of Health

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2 relations

Broader (2)

Multienzyme Complexespeptide synthase

Papers overview

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Highly Cited
2013
Highly Cited
2013
The Genome of Tolypocladium inflatum: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster
The ascomycete fungus Tolypocladium inflatum, a pathogen of beetle larvae, is best known as the producer of the immunosuppressant… 
Highly Cited
2001
Highly Cited
2001
Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladium inflatum
Abstract. The electron microscopic image of native cyclosporin synthetase molecules showed large globular complexes of 25 nm in… 
1997
1997
Prediction of substrate‐specific pockets in cyclosporin synthetase
Highly Cited
1994
Highly Cited
1994
The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame
Cyclosporin A, a potent and clinically-important immunosuppressive drug (SandimmunR), is synthesized from its precursor amino… 
Highly Cited
1994
Highly Cited
1994
Mechanism of cyclosporin A biosynthesis. Evidence for synthesis via a single linear undecapeptide precursor.
Highly Cited
1993
Highly Cited
1993
Substrate specificities of cyclosporin synthetase and peptolide SDZ 214-103 synthetase. Comparison of the substrate specificities of the related multifunctional polypeptides.
The recently discovered multifunctional polypeptide cyclosporin synthetase is capable of synthesizing the cyclic undecapeptide… 
1992
1992
Enzymatic biosynthesis of cyclosporin A and analogues.
1991
1991
In vitro biosynthesis of [Thr2,Leu5,D-Hiv8,Leu10]-cyclosporin, a cyclosporin-related peptolide, with immunosuppressive activity by a multienzyme polypeptide.
Highly Cited
1990
Highly Cited
1990
Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described.
1990
1990
Isolation and partial characterization of cyclosporin synthetase from a cyclosporin non-producing mutant of Beauveria nivea.
Cyclosporin synthetase was isolated from a cyclosporin non-producing mutant of Beauveria nivea, strain YP 582. The enzyme has a… 
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