cullin-3

Known as: CUL3, Cullin Homolog 3, CUL-3 
Cullin-3 (768 aa, ~89 kDa) is encoded by the human CUL3 gene. This protein plays a role in protein ubiquitination and cell cycle arrest.
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
The simplicity of programming the CRISPR (clustered regularly interspaced short palindromic repeats)–associated nuclease Cas9 to… (More)
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Highly Cited
2013
Highly Cited
2013
Pseudohypoaldosteronism type II (PHAII) is a rare Mendelian syndrome featuring hypertension and hyperkalemia resulting from… (More)
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Highly Cited
2012
Highly Cited
2012
Hypertension affects one billion people and is a principal reversible risk factor for cardiovascular disease… (More)
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Highly Cited
2006
Highly Cited
2006
Dishevelled is a conserved protein that interprets signals received by Frizzled receptors. Using a tandem-affinity purification… (More)
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Highly Cited
2005
Highly Cited
2005
The concentrations and functions of many eukaryotic proteins are regulated by the ubiquitin pathway, which consists of ubiquitin… (More)
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Highly Cited
2004
Highly Cited
2004
Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress proteins in… (More)
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Highly Cited
2003
Highly Cited
2003
The concentrations and functions of many cellular proteins are regulated by the ubiquitin pathway. Cullin family proteins bind… (More)
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Highly Cited
2003
Highly Cited
2003
Programmed destruction of regulatory proteins through the ubiquitin–proteasome system is a widely used mechanism for controlling… (More)
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Highly Cited
2003
Highly Cited
2003
Many biological processes, such as development and cell cycle progression are tightly controlled by selective ubiquitin-dependent… (More)
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Highly Cited
1999
Highly Cited
1999
Cyclin E is an unstable protein that is degraded in a ubiquitin- and proteasome- dependent pathway. Two factors stimulate cyclin… (More)
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