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cremophor EL

Known as: cremophore EL 
National Institutes of Health

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4 relations

Broader (2)

GlycerinSurface-Active Agents
analogs & derivativespolyoxyl 35 castor oil

Papers overview

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2019
2019
PEGylation of lipophilic SN38 prodrug with DSPE-mPEG2000 versus cremophor EL: comparative study for intravenous chemotherapy
Abstract The lipophilic prodrug of hydrophobic drugs with well-designed molecular structures can form stable pure prodrug… 
2008
2008
Integrity of liposomes in presence of various formulation excipients, when dispersed in aqueous media and in hydrogels.
2005
2005
Polysorbate 80 and Cremophor EL micelles deaggregate and solubilize nystatin at the core-corona interface.
The extent and the location of nystatin solubilization by nonionic surfactant micelles were determined. The critical aggregation… 
2005
2005
Paclitaxel in a novel formulation containing less Cremophor EL as first-line therapy for advanced breast cancer: A phase II trial
SummaryPaclitaxel (Taxol) is formulated in 50% Cremophor EL (CrEL)/absolute ethanol for clinical use. In order to reduce vehicle… 
2000
2000
Cremophor EL pharmacokinetics in a phase I study of paclitaxel (Taxol®) and carboplatin in non-small cell lung cancer patients
The purpose of our study was to investigate the pharmacokinetics of Cremophor EL following administration of escalating doses of… 
1998
1998
Effect of Cremophor EL on the pharmacokinetics, antitumor activity and toxicity of doxorubicin in mice
Cremophor EL (CR) is a solubllizing agent and a modulator of P-glycoprotein (P-gp)-medlated antlcancer multidrug resistance. The… 
1997
1997
Differential activity of cremophor EL and paclitaxel in patients' tumor cells and human carcinoma cell lines in vitro
Previous studies indicate that Cremophor EL (CEL), the excipient for Taxol, a clinical preparation of paclitaxel, has biologic… 
1995
1995
Haematopoietic radioprotection by Cremophor EL: a polyethoxylated castor oil.
The polyethoxylated castor oil, Cremophor EL (Cremophor) is approved for human use as a vehicle for oral and intravenous… 
1993
1993
Binding of drugs to human plasma proteins, exemplified by Sn(IV)-etiopurpurin dichloride delivered in cremophor and DMSO.
1991
1991
THE INFLUENCE OF THE CYCLOSPORINE VEHICLE, CREMOPHOR EL, ON RENAL MICROVASCULAR BLOOD FLOW IN THE RAT
Cyclosporine nephrotoxicity may be due to glomerular hypoperfusion. Previous experimental and clinical studies have demonstrated… 
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