creatine biosynthetic process

Known as: creatine anabolism, creatine synthesis, creatine biosynthesis 
The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process… (More)
National Institutes of Health

Papers overview

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Review
2007
Review
2007
Creatine: endogenous metabolite, dietary, and therapeutic supplement.
Creatine and phosphocreatine serve not only as an intracellular buffer for adenosine triphosphate, but also as an energy shuttle… (More)
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Highly Cited
2006
Highly Cited
2006
Is it time to reevaluate methyl balance in humans?
S-Adenosylmethionine (AdoMet) is the major biological methyl donor. AdoMet's methyl group arises both from the diet (eg… (More)
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2005
2005
Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh.
BACKGROUND Indian Asian men residing in the United Kingdom have a higher prevalence of hyperhomocysteinemia than do their… (More)
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Highly Cited
2004
Highly Cited
2004
Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis.
The creatine/phosphocreatine shuttle system, as catalysed reversibly by creatine kinases, is thought to be essential for the… (More)
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Review
2002
Review
2002
Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease?
Major achievements made over the last several years have highlighted the important roles of creatine and the creatine kinase… (More)
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Highly Cited
2001
Highly Cited
2001
Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans.
Arginine:glycine amidinotransferase (AGAT) catalyzes the first step of creatine synthesis, resulting in the formation of… (More)
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Highly Cited
2001
Highly Cited
2001
Endogenous synthesis and transport of creatine in the rat brain: an in situ hybridization study.
Creatine is synthesized from arginine by L-arginine:glycine amidinotransferase (AGAT) and S-adenosyl-L-methionine:N… (More)
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Highly Cited
1996
Highly Cited
1996
Creatine replacement therapy in guanidineoacetate methyltransferase deficiency, a novel inborn error of metabolism
BACKGROUND The creatine/creatine-phosphate system is essential for the storage and transmission of phosphate-bound energy in… (More)
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Highly Cited
1994
Highly Cited
1994
Creatine Deficiency in the Brain: A New, Treatable Inborn Error of Metabolism
ABSTRACT: In a patient with extrapyramidal movement disorder and extremely low creatinine concentrations in serum and urine, in… (More)
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Review
1994
Review
1994
Creatine in humans with special reference to creatine supplementation.
Since the discovery of creatine in 1832, it has fascinated scientists with its central role in skeletal muscle metabolism. In… (More)
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