cosalane
National Institutes of Health
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Abstract Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV…
Cosalane and its synthetic derivatives inhibit the binding of gp120 to CD4 as well as the fusion of the viral envelope with the…
Cosalane is a potent inhibitor of HIV replication with multiple sites of action. The purposes of this study were to (a) determine…
Cosalane is a potent inhibitor of HIV replication with activity against a broad range of viral targets. However, the oral…
The anti-HIV agent cosalane inhibits both the binding of gp120 to CD4 as well as an undefined postattachment event prior to…
AbstractPurpose. The selection of cosalane (NSC 658586) by the National Cancer Institute for further development as a potential…
In order to define the role of the cholestane moiety in the anti-HIV agent cosalane, a series of cosalane analogs was synthesized…
Several new analogues of the novel anti-HIV agent cosalane have been synthesized and evaluated as inhibitors of HIV-1 integrase…
Cosalane (3), a novel anti-HIV agent having a disalicylmethane unit linked to C-3 of cholestane by a three-carbon linker, was…