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cosalane

 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Anti-HIV AgentsAurintricarboxylic Acid

Narrower (1)

NSC 658586
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Intrinsic Solubility Estimation and pH-Solubility Behavior of Cosalane (NSC 658586), an Extremely Hydrophobic Diprotic Acid
AbstractPurpose. The selection of cosalane (NSC 658586) by the National Cancer Institute for further development as a potential… Expand
2003
2003
Enhanced transport of a novel anti-HIV agent--cosalane and its congeners across human intestinal epithelial (Caco-2) cell monolayers.
PURPOSE Cosalane is a potent inhibitor of HIV replication with activity against a broad range of viral targets. However, oral… Expand
Review
2001
Review
2001
New developments in anti-HIV chemotherapy
  • E. De Clercq
  • Current medicinal chemistry
  • 2001
    • Corpus ID: 23439270
Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV infections… Expand
2001
2001
Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores.
Cosalane and its synthetic derivatives inhibit the binding of gp120 to CD4 as well as the fusion of the viral envelope with the… Expand
2000
2000
Transport of cosalane-a highly lipophilic novel anti-HIV agent-across caco-2 cell monolayers.
Cosalane is a potent inhibitor of HIV replication with activity against a broad range of viral targets. However, the oral… Expand
1999
1999
Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.
The anti-HIV agent cosalane inhibits both the binding of gp120 to CD4 as well as an undefined postattachment event prior to… Expand
1996
1996
Correlation of anti-HIV potency with lipophilicity in a series of cosalane analogs having normal alkenyl and phosphodiester chains as cholestane replacements.
In order to define the role of the cholestane moiety in the anti-HIV agent cosalane, a series of cosalane analogs was synthesized… Expand
1996
1996
Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues.
The effects of linker chain modifications were investigated in a series of cosalane analogues. The modifications investigated… Expand
Highly Cited
1995
Highly Cited
1995
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.
Several new analogues of the novel anti-HIV agent cosalane have been synthesized and evaluated as inhibitors of HIV-1 integrase… Expand
1994
1994
Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction.
Cosalane (3), a novel anti-HIV agent having a disalicylmethane unit linked to C-3 of cholestane by a three-carbon linker, was… Expand
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