cortisol biosynthetic process

Known as: cortisol biosynthesis, cortisol formation, cortisol synthesis 
The chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione… (More)
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer.
CONTEXT Abiraterone acetate is a small-molecule cytochrome P450 17A1 (CYP17A1) inhibitor that is active in castration-resistant… (More)
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Highly Cited
2011
Highly Cited
2011
Stress-related noradrenergic activity prompts large-scale neural network reconfiguration.
Acute stress shifts the brain into a state that fosters rapid defense mechanisms. Stress-related neuromodulators are thought to… (More)
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Highly Cited
2010
Highly Cited
2010
Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism.
We report the first administration of an orally active aldosterone synthase inhibitor, LCI699, to 14 patients with primary… (More)
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Review
2009
Review
2009
Molecular programming of the corticosteroid stress axis during zebrafish development.
The functions of the hypothalamus-pituitary-interrenal (HPI) axis in teleosts have been studied primarily in juvenile and adult… (More)
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2008
2008
Approach to the adult with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Congenital adrenal hyperplasia (CAH) describes a group of autosomal recessive disorders where there is impairment of cortisol… (More)
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Review
2007
Review
2007
Differential expression of HPA axis homolog in the skin
Human skin expresses elements of the hypothalamo-pituitary-adrenal (HPA) axis including pro-opiomelanocortin (POMC… (More)
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Highly Cited
2004
Highly Cited
2004
Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss.
OBJECTIVES The activity of adipose 11beta-hydroxysteroid dehydrogenase (11beta-HSD) 1 is increased in obese subjects, and animal… (More)
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Review
2004
Review
2004
Recent advances in the diagnosis and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Congenital adrenal hyperplasias (CAH) are inherited defects of cortisol biosynthesis. More than 90% of CAH are caused by 21… (More)
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Highly Cited
1997
Highly Cited
1997
Decreased hypothalamic-pituitary-adrenal axis sensitivity to cortisol feedback inhibition in human aging.
Aging-related reduction in the sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis to glucocorticoid feedback inhibition… (More)
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Highly Cited
1994
Highly Cited
1994
Increased evening activation of the hypothalamic-pituitary-adrenal axis in depressed patients.
OBJECTIVE To determine whether depressed patients demonstrate hypothalamic-pituitary-adrenal (HPA) axis activation during the… (More)
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