correolide
National Institutes of Health
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Kv1.3‐channels are critically involved in activation and function of effector memory T cells. Blocking Kv1.3‐channels was…
Remillard CV, Tigno DD, Platoshyn O, Burg ED, Brevnova EE, Conger D, Nicholson A, Rana BK, Channick RN, Rubin LJ, O’Connor DT…
Coronary blood flow control is not uniform along the vascular tree and particularly between the right coronary artery and the…
See related article, pages 53–60
Resistance arteries possess an intrinsic ability to constrict in response to increased…
To the Editor:
We have read with interest the recent article published by Circulation Research entitled “Heteromultimeric Kv1…
[reaction: see text] Pentacyclic triterpenoid natural product correolide (1) was converted to ketone 2 via ozonolysis. An unusual…
Correolide is a novel immunosuppressant that inhibits the voltage-gated potassium channel K(v)1.3 [Felix et al. (1999…
Correolide (1–10 μM), a nortriterpene purified from Spachea correae and a selective blocker of Kv1 potassium channels, elicits…