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compstatin

 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Therapeutic modulation of the complement system has become increasingly important in line with the growing recognition of the… Expand
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Highly Cited
2011
Highly Cited
2011
Compstatin is a 13-residue disulfide-bridged peptide that inhibits a key step in the activation of the human complement system… Expand
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Review
2008
Review
2008
Therapeutic modulation of the human complement system is considered a promising approach for treating a number of pathological… Expand
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Highly Cited
2007
Highly Cited
2007
Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to several… Expand
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Highly Cited
2006
Highly Cited
2006
Tryptophans at positions 4 and 7 of compstatin, a peptide complement inhibitor, are crucial for its interaction with C3. However… Expand
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Highly Cited
2005
Highly Cited
2005
We present new findings in our drug discovery effort to develop an anticomplement therapeutic. We have designed several active… Expand
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Highly Cited
2003
Highly Cited
2003
Although activation of complement protein C3 is essential for the generation of normal inflammatory responses against pathogens… Expand
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2002
2002
We have previously identified compstatin, a 13-residue cyclic peptide, that inhibits complement activation by binding to C3 and… Expand
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Highly Cited
1998
Highly Cited
1998
The third component of complement, C3, plays a central role in activation of the classical, alternative, and lectin pathways of… Expand
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1998
1998
Recently, a C3-binding cyclic synthetic peptide (Compstatin) has been identified that binds to complement component C3 and… Expand
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