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compstatin

National Institutes of Health

Papers overview

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Review
2015
Review
2015
There is a growing awareness that complement plays an integral role in human physiology and disease, transcending its traditional… 
Highly Cited
2008
Highly Cited
2008
Abstract:  Background:  A massive destruction of transplanted tissue occurs immediately following transplantation of pancreatic… 
Review
2008
Review
2008
Therapeutic modulation of the human complement system is considered a promising approach for treating a number of pathological… 
Highly Cited
2007
Highly Cited
2007
Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to several… 
Highly Cited
2006
Highly Cited
2006
Tryptophans at positions 4 and 7 of compstatin, a peptide complement inhibitor, are crucial for its interaction with C3. However… 
Highly Cited
2005
Highly Cited
2005
We present new findings in our drug discovery effort to develop an anticomplement therapeutic. We have designed several active… 
Highly Cited
2000
Highly Cited
2000
Complement activation products are major components of the inflammatory response induced by cardiac surgery and cardiopulmonary… 
Highly Cited
1999
Highly Cited
1999
Fiane AE, Mollnes TE, Videm V, Hovig T, Høgåsen K, Mellbye OJ, Spruce L, Moore WT, Sahu A, Lambris JD. Compstatin, a peptide… 
Highly Cited
1998
Highly Cited
1998
The third component of complement, C3, plays a central role in activation of the classical, alternative, and lectin pathways of…