compstatin
National Institutes of Health
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The complement system and the Toll‐like (TLR) co‐receptor CD14 play important roles in innate immunity and sepsis. Tissue factor…
We report the computational and rational design of new generations of potential peptide‐based inhibitors of the complement…
The development of compounds to regulate the activation of the complement system in non‐primate species is of profound interest…
Compstatin and its active peptide analogs can potentially be used for therapeutic purposes because their binding to the third…
Compstatin is a 13-residue cyclic peptide that has the ability to inhibit the cleavage of C3 to C3a and C3b. The effects of…
Compstatin is a 13-residue cyclic peptide that inhibits complement activation by binding to complement component, C3. Although…
Compstatin is a 13‐residue cyclic peptide that has the potential to become a therapeutic agent against unregulated complement…
BACKGROUND
Whereas complement is a key mediator of hyperacute xenograft rejection, its role in acute vascular rejection (AVR) is…