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Nonsense mutations resulting in a premature stop codon in an open reading frame occur in critical tumor suppressor genes in a… Expand Among anti-cancer candidate drugs, TRAIL might be the most specific agent against cancer cells due to its low toxicity to normal… Expand Drug resistance is a major reason for therapy failure in cancer. Clitocine is a natural amino nucleoside isolated from mushroom… Expand ABT-737 is a novel anti-apoptotic Bcl-2 family protein inhibitor with high affinity to Bcl-2, Bcl-xl and Bcl-w but relatively low… Expand Multidrug resistance(MDR)is one of the major reasons for failure in cancer chemotherapy and its suppression may increase the… Expand Clitocine, a natural biologically active substance isolated from the mushroom Leucopaxillus giganteus, possesses several… Expand A biologically guided fractionation from Lepista inversa (Scop.: Fr.) led to the isolation of clitocine, an exocyclic amino… Expand Adenosine kinase (AK) is the primary enzyme responsible for adenosine metabolism. Inhibition of AK effectively increases… Expand Abstract We describe the synthesis of two series of acyclonucleosides: carbaacyclonucleosides and 1′-oxaacyclonucleosides which… Expand The total synthesis of clitocine [6-amino-5-nitro-4-(beta-D-ribofuranosylamino)pyrimidine] (1), a nucleoside recently isolated… Expand