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Lichens—a promising source of bioactive secondary metabolites
A global approach of the lichen metabolomic features appears to be essential in developing new and viable biotechnological processes which could afford suitable amounts of unique lichen compounds.
Antiviral and cytotoxic activities of some Indonesian plants.
- F. Lohézic-Le Devehat, A. Bakhtiar, C. Bézivin, M. Amorós, J. Boustie
- Biology, MedicineFitoterapia
- 1 August 2002
Ten methanolic extracts from eight Indonesian medicinal plants were phytochemically screened and evaluated for antiviral (HSV-1 and Poliov virus) and cytotoxic activities on murine and human cancer lines and Piper aduncum (Piperaceae) was found active on Poliovirus.
Cytotoxic activity of some lichen extracts on murine and human cancer cell lines.
- C. Bézivin, S. Tomasi, F. Lohézic-Le Devehat, J. Boustie
- Medicine, BiologyPhytomedicine : international journal of…
Eight lichens were extracted successively with n-hexane, diethyl ether and methanol using a Soxhlet process and some extracts demonstrated interesting activities particularly on human cancer cell lines as good selectivity indices were recorded.
Stictic acid derivatives from the lichen Usnea articulata and their antioxidant activities.
- F. Lohézic-Le Devehat, S. Tomasi, +4 authors J. Boustie
- Chemistry, MedicineJournal of natural products
- 13 July 2007
Two new beta-orcinol depsidones, 1 and 2, together with 13 known compounds were isolated from the lichen Usnea articulata and exhibited moderate antiradical activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.
Lichenic extracts and metabolites as UV filters.
- F. Lohézic-Le Devehat, B. Legouin, C. Couteau, J. Boustie, L. Coiffard
- Chemistry, MedicineJournal of photochemistry and photobiology. B…
- 5 March 2013
Three lichen extracts and ten lichenic compounds have been screened for their photoprotective activities and among them, a Lasallia pustulata extract and gyrophoric acid exhibited SPF values over 5, which is better than Homosalate (SPF≈4).
Bioactive lichen metabolites: alpine habitats as an untapped source
Some of the antimicrobial, anti-inflammatory, antiproliferative and antioxidant activities properties described in lichens appear to harbour a diversity of culturable microorganisms from which active compounds have been isolated recently.
Cytotoxic activity of compounds from the lichen: Cladonia convoluta.
- C. Bézivin, S. Tomasi, I. Rouaud, J. Delcros, J. Boustie
- Medicine, BiologyPlanta medica
- 1 September 2004
The complete structure of 9'-( O-methyl)protocetraric acid was elucidated using HSQC and HMBC spectral data and was shown to induce apoptosis of murine leukaemia L1210 cells in a dose- and time-dependent manner.
Synthesis and cytotoxic activities of usnic acid derivatives.
- M. Bazin, A. Le Lamer, +5 authors S. Tomasi
- Chemistry, MedicineBioorganic & medicinal chemistry
- 15 July 2008
The more active derivative (1,8-diaminooctane derivative) displayed similar activities on all cancer cell lines studied and induced apoptosis and alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, had no effect on the activity of the polyamine derivatives.
Cytotoxic activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell lines.
- S. Tomasi, F. Lohézic-Le Devehat, P. Sauleau, C. Bézivin, J. Boustie
- Medicine, ChemistryDie Pharmazie
- 1 April 2004
Four mushroom species exhibited a significant cytotoxic activity (IC50 < or = 20 microg/ml) against at least one of the two murine cancer cell lines (Ganoderma lucidum, Meripilus giganteus, Suillus granulatus, S. luteus, and Polyporales and Boletales).
Characterization and identification of mycosporines-like compounds in cyanolichens. Isolation of mycosporine hydroxyglutamicol from Nephroma laevigatum Ach.
The optimized analytical protocol allowed the characterization of mycosporine-like compounds in small amounts of material and confirmed the potential of cyanolichens as a source of my cosporine compounds.