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clerocidin

Known as: 1-Naphthalenecarboxaldehyde, 5,5'-((tetrahydro-3'a,7'a-dihydroxydispiro(oxirane-2,3'(2'H)-difuro(2,3-b:2',3'-e)(1,4)dioxin-7'(6'H),2''-oxirane)-2',6'-diyl)bis(methylene))bis(3,4,4a,5,6,7,8,8a-octahydro-5,6,8a-trimethyl) 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

Antibiotic PR 1350

Broader (1)

Diterpenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Clerocidin-mediated DNA footprinting discriminates among different G-quadruplex conformations and detects tetraplex folding in a duplex environment.
2008
2008
Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA… 
2005
2005
Dissecting reactivity of clerocidin toward common buffer systems by means of selected drug analogues.
The model drug clerocidin (CL) can form covalent adducts with both Tris and phosphate buffers with negative effects on biological… 
2002
2002
Stereoselective synthesis of the fully functionalized core fragment of terpentecin
2001
2001
Investigation of the biological mode of action of clerocidin using whole cell assays.
1999
1999
Genomic sites of topoisomerase II activity determined by comparing DNA breakage enhanced by three distinct poisons.
To define the sites of topoisomerase II activity in two genomic regions of Drosophila melanogaster Kc cells, we have investigated… 
1998
1998
Total Synthesis of Clerocidin via a Novel, Enantioselective Homoallenylboration Methodology.
Received July 9, 1998 Clerocidin (1),1 terpentecin (2),2 and UCT4B (3)3 (Figure 1) are recently isolated diterpenoid antibiotics… 
1991
1991
Induction of a heat-stable topoisomerase II-DNA cleavable complex by nonintercalative terpenoides, terpentecin and clerocidin.
Terpentecin and clerocidin, microbial terpenoides, have been known to be potent antitumor antibiotics. However, the critical… 
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