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Role of Diacylglycerol in PKD Recruitment to the TGN and Protein Transport to the Plasma Membrane
Reducing cellular levels of DAG inhibited PKD recruitment and blocked protein transport from the TGN to the cell surface, and a DAG-dependent, PKD-mediated signaling regulates the formation of transport carriers in mammalian cells. Expand
Signaling via Mitogen-Activated Protein Kinase Kinase (MEK1) Is Required for Golgi Fragmentation during Mitosis
An assay using permeabilized cells to monitor fragmentation of the Golgi complex that occurs during mitosis finds a Golgi-associated ERK, which is proposed as the likely target for MEK1 in Golgi fragmentation. Expand
CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease.
It is reported that CP110 interacts with CEP290--a protein whose deficiency is implicated in human ciliary disease--in a discrete complex separable from other CP110 complexes involved in regulating the centrosome cycle. Expand
Unconventional secretion of Acb1 is mediated by autophagosomes
Evidence is presented for an unconventional protein secretion pathway that is conserved from yeast to Dictyostelium discoideum in which Acb1 may be sequestered into autophagosomal vesicles, whichExpand
Protein Kinase D Regulates the Fission of Cell Surface Destined Transport Carriers from the Trans-Golgi Network
It is suggested that PKD regulates the fission from the TGN of transport carriers that are en route to the cell surface and prevents the transfer of cargo from TGN to the plasma membrane. Expand
Functional genomics reveals genes involved in protein secretion and Golgi organization
It is shown that depletion of class A genes redistributes Golgi membranes into the endoplasmic reticulum, depletion of classes B, C, and D genes leads to Golgi fragmentation, and depletion ofclass D genes causes no obvious change. Expand
The formation of TGN-to-plasma-membrane transport carriers.
  • F. Bard, V. Malhotra
  • Biology, Medicine
  • Annual review of cell and developmental biology
  • 9 October 2006
This work describes the current understanding of the TGN-to-cell-surface carriers, with a specific focus on the components involved in membrane fission. Expand
TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites
It is proposed that TANGO1 exports other cargoes in cells that do not secrete collagen VII and does not enter the budding carrier, which represents a unique mechanism to load cargo into COPII carriers. Expand
The Golgi-associated protein GRASP65 regulates spindle dynamics and is essential for cell division.
The results suggest the requirement for GRASP65 in the regulation of spindle dynamics rather than a direct role in the stacking of Golgi cisternae, and provide evidence that the expression of the C-terminus of GRasP65 interferes with entry of cells into mitosis. Expand
Dimeric PKD regulates membrane fission to form transport carriers at the TGN
It is demonstrated that PKD regulates membrane fission and this activity is used to control the size of transport carriers, and to prevent uncontrolled vesiculation of TGN during protein transport. Expand