cixutumumab

Known as: Anti-IGF-1R Recombinant Monoclonal Antibody IMC-A12 
A fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2008-2017
05101520082017

Papers overview

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2014
2014
BACKGROUND & AIMS IGF-IR is implicated in hepatic carcinogenesis. This and preliminary evidence of biological activity of anti… (More)
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2014
2014
BACKGROUND No standard treatment exists for refractory or relapsed advanced thymic epithelial tumours. We investigated the… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Preclinical studies have shown synergistic antitumour activity by inhibition of insulin-like growth factor-1 receptor… (More)
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2013
2013
BACKGROUND Cixutumumab (IMC-A12), a fully human immunoglobulin G1 (IgG1) monoclonal antibody, exerts preclinical activity in… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE Temsirolimus was combined with cixutumumab, a fully human IgG1 monoclonal antibody directed at the insulin growth factor… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE A phase I/II study of cixutumumab (IMC-A12) in children with refractory solid tumors was conducted. This study was… (More)
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2012
2012
INTRODUCTION This phase I/II study evaluated the safety and antitumor effect of the combination of erlotinib with cixutumumab, a… (More)
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2011
2011
PURPOSE Mammalian target of rapamycin (mTOR) inhibitors mediate AKT activation through a type 1 insulin-like growth factor… (More)
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2011
2011
10031 Background: In this multicenter NCI CTEP-sponsored trial [funded by R21CA13763301A1 (AN), U01CA62461 (RK), and U01CA62487… (More)
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2011
2011
Recent reports have shown limited anticancer therapeutic efficacy of insulin-like growth factor receptor (IGF-1R)-targeted… (More)
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