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cixutumumab

Known as: Anti-IGF-1R Recombinant Monoclonal Antibody IMC-A12 
A fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Background Prognostic studies of insulin-like growth factor-1 receptor(IGF-1R) inhibitors in cancer therapy had promising results… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND The combined inhibition of insulin-growth factor type 1 receptor (IGF-1R) and the mammalian target of rapamycin (mTOR… Expand
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2015
2015
Purpose: This phase II trial evaluated the efficacy and safety of cixutumumab, a human anti–insulin-like growth factor receptor 1… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND No standard treatment exists for refractory or relapsed advanced thymic epithelial tumours. We investigated the… Expand
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Highly Cited
2014
Highly Cited
2014
PURPOSE This phase 2 study was designed to assess the efficacy of single agent cixutumumab (IMC-A12) and gain further information… Expand
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2014
2014
Adrenocortical carcinoma (ACC) is an aggressive malignancy, which lacks an effective systemic treatment. Abnormal activation of… Expand
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Preclinical studies have shown synergistic antitumour activity by inhibition of insulin-like growth factor-1 receptor… Expand
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Highly Cited
2013
Highly Cited
2013
Background:Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy without an available effective systemic… Expand
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Highly Cited
2012
Highly Cited
2012
Purpose: Temsirolimus was combined with cixutumumab, a fully human IgG1 monoclonal antibody directed at the insulin growth factor… Expand
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Highly Cited
2012
Highly Cited
2012
PURPOSE A phase I/II study of cixutumumab (IMC-A12) in children with refractory solid tumors was conducted. This study was… Expand
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