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cilofungin

Known as: 1-[(4R,5R)-4,5-Dihydroxy-N2-[p-(octyloxy)benzoyl]-L-ornithine]echinocandin B, Echinocandin B, 1-((4R,5R)-4,5-dihydroxy-N2-(4-(octyloxy)benzoyl)-L-ornithine)- 
A narrow-spectrum cyclic lipopeptide derivative of echinocandin B derived from Aspergillus with fungicidal activity.
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Antifungal AgentsEchinocandins

Narrower (2)

L 646991LY 121019

Papers overview

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2005
2005
Effect of cilofungin on phagocytosis and intracellular killing ofCandida albicans by human neutrophils
The effect of a beta glucan synthase inhibitor, cilofungin, amphotericin B and 5-fluorocytosine on opsonization, phagocytosis and… 
Review
1992
Review
1992
Experimental antifungal chemotherapy in granulocytopenic animal models of disseminated candidiasis: approaches to understanding investigational antifungal compounds for patients with neoplastic…
Disseminated candidiasis is the most common life-threatening invasive fungal infection in granulocytopenic patients. A review of… 
1991
1991
W-1 solubilization and kinetics of inhibition by cilofungin of Candida albicans (1,3)-beta-D-glucan synthase
(1,3)-beta-D-Glucan synthase of Candida albicans was rendered soluble by treatment of membrane preparations with the… 
1990
1990
Cilofungin (LY121019) shows nonlinear plasma pharmacokinetics and tissue penetration in rabbits
We studied the plasma pharmacokinetics and tissue penetration of cilofungin (LY121019), a new echinocandin antifungal compound… 
1990
1990
Comparative effects of cilofungin and amphotericin B on experimental murine candidiasis
The effectiveness of cilofungin (LY121019, referred to hereafter as LY), a lipopeptide, was studied in a murine candidiasis model… 
1990
1990
Comparison of cilofungin and amphotericin B for therapy of murine candidiasis
We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis. Three… 
1990
1990
Retinal toxicity and in vitro efficacy study of cilofungin (LY121019).
We assessed the retinal toxicity of a new antifungal agent, cilofungin, by injecting it into the vitreous body of albino rabbit… 
1989
1989
Treatment of experimental disseminated candidiasis with cilofungin
The efficacy of cilofungin treatment of experimental disseminated candidiasis in rabbits was examined. Cilofungin treatment… 
1989
1989
Evaluation of cilofungin, a lipopeptide antifungal agent, in vitro against fungi isolated from clinical specimens
Cilofungin (LY121019) is a new lipopeptide antifungal drug. We tested this drug against 141 pathogenic fungal isolates. All… 
1989
1989
Effects of cilofungin (LY121019) on carbohydrate and sterol composition ofCandida albicans
Cilofungin (LY121019) is a novel analogue of echinocandin B with potent activity againstCandida albicans. The effects of… 
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