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cilobradine

 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

BenzazepinesPiperidines

Narrower (1)

DK-AH 269

Papers overview

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2012
2012
Joint Population Pharmacokinetic/Pharmacodynamic Model for the Heart Rate Effects at Rest and at the End of Exercise for Cilobradine
ABSTRACTPurposeTo develop a semi-mechanistic population pharmacokinetic/pharmacodynamic (PKPD) model for the selective… Expand
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2011
2011
HCN Channels Expressed in the Inner Ear Are Necessary for Normal Balance Function
HCN1–4 subunits form Na+/K+-permeable ion channels that are activated by hyperpolarization and carry the current known as Ih. Ih… Expand
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2008
2008
Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells
Aims/hypothesisThe hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels, discovered initially in cardiac and… Expand
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2007
2007
Population Pharmacokinetic Data Analysis of Cilobradine, an If Channel Blocker
PurposeTo evaluate the population pharmacokinetic characteristics of cilobradine including a covariate analysis based on six… Expand
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2007
2007
Molecular Mapping of the Binding Site for a Blocker of Hyperpolarization-Activated, Cyclic Nucleotide-Modulated Pacemaker Channels
Hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels mediate rhythmic electrical activity of neural and… Expand
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Review
2007
Review
2007
Molecular regulation and pharmacology of pacemaker channels.
The spontaneous activity of cardiac tissue originates in specialized pacemaker cells in the sino-atrial node that generate… Expand
2007
2007
Bradycardic Therapy Improves Left Ventricular Function and Remodeling in Dogs with Coronary Embolization-Induced Chronic Heart Failure
Both β-adrenergic blockade and bradycardia may contribute to the therapeutic effect of β-blockers in chronic heart failure (CHF… Expand
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Highly Cited
2006
Highly Cited
2006
Bradycardic and Proarrhythmic Properties of Sinus Node Inhibitors
Sinus node inhibitors reduce the heart rate presumably by blocking the pacemaker current If in the cardiac conduction system… Expand
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Highly Cited
2003
Highly Cited
2003
Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine.
The action of the bradycardiac agents, cilobradine (DK-AH269) and zatebradine (UL-FS49), on the cardiac pacemaker current (If… Expand
Highly Cited
2003
Highly Cited
2003
Comparison between invasive hemodynamic measurements and noninvasive assessment of left ventricular diastolic function by use of Doppler echocardiography in healthy anesthetized cats.
OBJECTIVE To compare Doppler echocardiographic variables of left ventricular (LV) function with those obtained invasively via… Expand
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