cilobradine
National Institutes of Health
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To develop a semi-mechanistic population pharmacokinetic/pharmacodynamic (PKPD) model for the selective bradycardic agent…
Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate the rhythmic beating of mammalian hearts. We…
Ivabradine represents a novel heart-rate-lowering agent that acts on the sino-atrial node supposedly by selectively inhibiting…
PurposeTo evaluate the population pharmacokinetic characteristics of cilobradine including a covariate analysis based on six…
Aims/hypothesisThe hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels, discovered initially in cardiac and…
The present invention provides the use in a pharmaceutical composition of a specific cyclic amine derivative, or its…