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cilobradine

National Institutes of Health

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3 relations

Broader (2)

BenzazepinesPiperidines

Narrower (1)

DK-AH 269

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Inhibitory Effective Perturbations of Cilobradine (DK-AH269), A Blocker of HCN Channels, on the Amplitude and Gating of Both Hyperpolarization-Activated Cation and Delayed-Rectifier Potassium…
Cilobradine (CIL, DK-AH269), an inhibitor of hyperpolarization-activated cation current (Ih), has been observed to possess pro… 
2011
2011
HCN Channels Expressed in the Inner Ear Are Necessary for Normal Balance Function
HCN1–4 subunits form Na+/K+-permeable ion channels that are activated by hyperpolarization and carry the current known as Ih. Ih… 
2010
2010
Uni- or bi-ventricular hypertrophy and susceptibility to drug-induced torsades de pointes.
2008
2008
Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells
Aims/hypothesisThe hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels, discovered initially in cardiac and… 
Highly Cited
2007
Highly Cited
2007
Molecular Mapping of the Binding Site for a Blocker of Hyperpolarization-Activated, Cyclic Nucleotide-Modulated Pacemaker Channels
Hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels mediate rhythmic electrical activity of neural and… 
2007
2007
Population Pharmacokinetic Data Analysis of Cilobradine, an If Channel Blocker
PurposeTo evaluate the population pharmacokinetic characteristics of cilobradine including a covariate analysis based on six… 
Review
2007
Review
2007
Molecular regulation and pharmacology of pacemaker channels.
The spontaneous activity of cardiac tissue originates in specialized pacemaker cells in the sino-atrial node that generate… 
Highly Cited
2006
Highly Cited
2006
Bradycardic and Proarrhythmic Properties of Sinus Node Inhibitors
Sinus node inhibitors reduce the heart rate presumably by blocking the pacemaker current If in the cardiac conduction system… 
Highly Cited
2003
Highly Cited
2003
Comparison between invasive hemodynamic measurements and noninvasive assessment of left ventricular diastolic function by use of Doppler echocardiography in healthy anesthetized cats.
OBJECTIVE To compare Doppler echocardiographic variables of left ventricular (LV) function with those obtained invasively via… 
Highly Cited
2003
Highly Cited
2003
Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine.
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