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cilobradine

 
National Institutes of Health

Papers overview

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2012
2012
ABSTRACTPurposeTo develop a semi-mechanistic population pharmacokinetic/pharmacodynamic (PKPD) model for the selective… Expand
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2011
2011
HCN1–4 subunits form Na+/K+-permeable ion channels that are activated by hyperpolarization and carry the current known as Ih. Ih… Expand
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2008
2008
Aims/hypothesisThe hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels, discovered initially in cardiac and… Expand
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2007
2007
PurposeTo evaluate the population pharmacokinetic characteristics of cilobradine including a covariate analysis based on six… Expand
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2007
2007
Hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels mediate rhythmic electrical activity of neural and… Expand
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Review
2007
Review
2007
The spontaneous activity of cardiac tissue originates in specialized pacemaker cells in the sino-atrial node that generate… Expand
2007
2007
Both β-adrenergic blockade and bradycardia may contribute to the therapeutic effect of β-blockers in chronic heart failure (CHF… Expand
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Highly Cited
2006
Highly Cited
2006
Sinus node inhibitors reduce the heart rate presumably by blocking the pacemaker current If in the cardiac conduction system… Expand
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Highly Cited
2003
Highly Cited
2003
The action of the bradycardiac agents, cilobradine (DK-AH269) and zatebradine (UL-FS49), on the cardiac pacemaker current (If… Expand
Highly Cited
2003
Highly Cited
2003
OBJECTIVE To compare Doppler echocardiographic variables of left ventricular (LV) function with those obtained invasively via… Expand