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cilobradine
National Institutes of Health
Watch Topic
Related topics
Related topics
3 relations
Broader (2)
Benzazepines
Piperidines
Narrower (1)
DK-AH 269
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Joint Population Pharmacokinetic/Pharmacodynamic Model for the Heart Rate Effects at Rest and at the End of Exercise for Cilobradine
Nieves Vélez de Mendizábal
,
Alexander Staab
,
+5 authors
Iñaki F. Trocóniz
Pharmaceutical Research
2012
ABSTRACTPurposeTo develop a semi-mechanistic population pharmacokinetic/pharmacodynamic (PKPD) model for the selective…
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2011
2011
HCN channels expressed in the inner ear are necessary for normal balance function.
Geoffrey C. Horwitz
,
Jessica R. Risner-Janiczek
,
Sherri M Jones
,
Jeffrey R Holt
The Journal of neuroscience : the official…
2011
HCN1-4 subunits form Na+/K+-permeable ion channels that are activated by hyperpolarization and carry the current known as I(h). I…
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2008
2008
Presence of functional hyperpolarisation-activated cyclic nucleotide-gated channels in clonal alpha cell lines and rat islet alpha cells
Yan Zhang
,
N. Zhang
,
+4 authors
Qidi Wang
Diabetologia
2008
Aims/hypothesisThe hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels, discovered initially in cardiac and…
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2007
2007
Population Pharmacokinetic Data Analysis of Cilobradine, an If Channel Blocker
Gabriele Fliss
,
Alexander Staab
,
Christiane Tillmann
,
Dirk Trommeshauser
,
Hans Guenter Schaefer
,
Charlotte Kloft
Pharmaceutical Research
2007
PurposeTo evaluate the population pharmacokinetic characteristics of cilobradine including a covariate analysis based on six…
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2007
2007
Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels.
L. Y. Cheng
,
Krista I Kinard
,
Ramkumar Rajamani
,
Michael C Sanguinetti
The Journal of pharmacology and experimental…
2007
Hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels mediate rhythmic electrical activity of neural and…
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Review
2007
Review
2007
Molecular regulation and pharmacology of pacemaker channels.
Patrick Bois
,
Romain Guinamard
,
Antoun E L Chemaly
,
J Faivre
,
Jocelyn Bescond
Current pharmaceutical design
2007
The spontaneous activity of cardiac tissue originates in specialized pacemaker cells in the sino-atrial node that generate…
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2007
2007
Bradycardic therapy improves left ventricular function and remodeling in dogs with coronary embolization-induced chronic heart failure.
Yanping Cheng
,
Isaac George
,
+12 authors
Jie Wang
The Journal of pharmacology and experimental…
2007
Both beta-adrenergic blockade and bradycardia may contribute to the therapeutic effect of beta-blockers in chronic heart failure…
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2006
2006
Bradycardic and proarrhythmic properties of sinus node inhibitors.
Juliane Stieber
,
Karen Wieland
,
Georg Stoeckl
,
Andreas Ludwig
,
Franz Hofmann
Molecular pharmacology
2006
Sinus node inhibitors reduce the heart rate presumably by blocking the pacemaker current If in the cardiac conduction system…
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2003
2003
Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine.
P P van Bogaert
,
François Pittoors
European journal of pharmacology
2003
The action of the bradycardiac agents, cilobradine (DK-AH269) and zatebradine (UL-FS49), on the cardiac pacemaker current (If…
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2003
2003
Comparison between invasive hemodynamic measurements and noninvasive assessment of left ventricular diastolic function by use of Doppler echocardiography in healthy anesthetized cats.
Karsten E. Schober
,
Virginia Luis Fuentes
,
John D. Bonagura
American journal of veterinary research
2003
OBJECTIVE To compare Doppler echocardiographic variables of left ventricular (LV) function with those obtained invasively via…
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