chaetominine

Drug resistance limits leukemia treatment and chaetominine, a cytotoxic alkaloid that promotes apoptosis in a K562 human leukemia… (More)

Chaetominine is a quinazoline alkaloid originating from the endophytic fungus Aspergillus fumigatus CY018. In this study, we… (More)

Chaetominine (CHA) is a quinazolinone alkaloid with strong anti-cancer activity produced by Aspergillus fumigatus CY018. For… (More)

The present study was designed to isolate and purify chemical constituents from solid culture of endophyte Aspergillus terreus LQ… (More)

A common dearomative strategy toward the kapakahines B/F and chaetominine natural products is reported. The proposed biomimetic… (More)

An efficient, asymmetric synthesis of the cytotoxic natural product chaetominine was achieved in 14 steps. The strategy employs a… (More)

The tricyclic hydroxy imidazolidinone was converted to chaetominine in seven steps in 22% overall yield. The key step was the… (More)