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chaetominine

 
National Institutes of Health

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Broader (1)

Indole Alkaloids

Papers overview

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2018
2018
Co-addition Strategy for Enhancement of Chaetominine from Submerged Fermentation of Aspergillus fumigatus CY018
Chaetominine (CHA), a novel framework tripeptide alkaloid, imparts an attractive cytotoxic against the human leukemia cell line… Expand
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2018
2018
Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells.
Chaetominine is a cytotoxic alkaloid that has been demonstrated to promote apoptotic cell death in human leukemia K562 cells. In… Expand
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2016
2016
Chaetominine reduces MRP1-mediated drug resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells.
Drug resistance limits leukemia treatment and chaetominine, a cytotoxic alkaloid that promotes apoptosis in a K562 human leukemia… Expand
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2016
2016
Adsorption characteristics and preparative separation of chaetominine from Aspergillus fumigatus mycelia by macroporous resin.
Chaetominine (CHA) is a quinazolinone alkaloid with strong anti-cancer activity produced by Aspergillus fumigatus CY018. For… Expand
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2016
2016
Assessment of the Cytotoxic and Apoptotic Effects of Chaetominine in a Human Leukemia Cell Line
Chaetominine is a quinazoline alkaloid originating from the endophytic fungus Aspergillus fumigatus CY018. In this study, we… Expand
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2016
2016
Improvement of chaetominine production by tryptophan feeding and medium optimization in submerged fermentation of Aspergillus fumigatus CY018
BackgroundChaetominine (CHA) is a novel alkaloid with excellent medicinal activities produced by Aspergillus fumigatus CY018… Expand
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2014
2014
Double annulative cascade of tryptophan-containing peptides triggered by selectfluor.
A common dearomative strategy toward the kapakahines B/F and chaetominine natural products is reported. The proposed biomimetic… Expand
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Highly Cited
2008
Highly Cited
2008
Total synthesis of chaetominine.
An efficient, asymmetric synthesis of the cytotoxic natural product chaetominine was achieved in 14 steps. The strategy employs a… Expand
2007
2007
Synthesis of (-)-chaetominine.
The tricyclic hydroxy imidazolidinone was converted to chaetominine in seven steps in 22% overall yield. The key step was the… Expand
Highly Cited
2006
Highly Cited
2006
Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015.
Chaetominine (1), an alkaloidal metabolite with a new framework, was characterized from the solid-substrate culture of Chaetomium… Expand
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