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ceramide glucosyltransferase activity

Known as: ceramide:UDPGlc glucosyltransferase activity, UDPglucose:N-acylsphingosine D-glucosyltransferase activity, UDP-glucose:N-acylsphingosine D-glucosyltransferase activity 
Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. [EC:2.4.1.80]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Enforced C-Src Activation Causes Compartmental Dysregulation of PI3K and PTEN Molecules in Lipid Rafts of Tongue Squamous Carcinoma Cells by Attenuating Rac1-Akt-GLUT-1-Mediated Sphingolipid…
Pharmacologic intervention to affect the membrane lipid homeostasis of lipid rafts is a potent therapeutic strategy for cancer… 
2017
2017
WP1066, a small molecule inhibitor of the JAK/STAT3 pathway, inhibits ceramide glucosyltransferase activity.
2016
2016
Cholesterol-dependent increases in glucosylceramide synthase activity in Niemann-Pick disease type C model cells: Abnormal trafficking of endogenously formed ceramide metabolites by inhibition of the…
2014
2014
Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation.
2013
2013
Glycolipid Transfer Protein Expression Is Affected by Glycosphingolipid Synthesis
Members of the glycolipid transfer protein superfamily (GLTP) are found from animals and fungi to plants and red micro-alga… 
2008
2008
Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin.
Bovine lactoferricin (LfcinB) is a cationic antimicrobial peptide that selectively induces apoptosis in several different types… 
Review
2005
Review
2005
P-glycoprotein--implications of metabolism of neoplastic cells and cancer therapy.
Multidrug resistance (MDR) of neoplastic tissues is a major obstacle in cancer chemotherapy. The predominant cause of MDR is the… 
Highly Cited
2004
Highly Cited
2004
Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.
BACKGROUND The lipid second messenger ceramide, which is generated by acidic and neutral sphingomyelinases or ceramide synthases… 
Highly Cited
2004
Highly Cited
2004
Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.
Resistance to natural product chemotherapy drugs is a major obstacle to successful cancer treatment. This type of resistance is… 
Highly Cited
2001
Highly Cited
2001
Modulation of epidermal growth factor receptor phosphorylation by endogenously expressed gangliosides.
The effect of changing the ganglioside composition of Chinese hamster ovary K1 cells on the function of the epidermal growth… 
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