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centrinone

 
National Institutes of Health

Papers overview

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2020
2020
Polo-like kinase 4 (PLK4) is the master regulator of centriole duplication in metazoan organisms. Catalytic activity and protein… Expand
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2019
2019
Polo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the centrosome in dividing cells. Its… Expand
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2018
2018
Here, we address the regulation of microtubule nucleation during interphase by genetically ablating one, or two, of three major… Expand
2018
2018
In the PNAS paper “Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers,” Kawakami et al. (1… Expand
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2018
2018
Centrosomes are the major microtubule-organizing centers in animal cells. Centrosomes catalyze microtubule assembly to accelerate… Expand
2018
2018
In “CFI-400945 is not a selective cellular PLK4 inhibitor,” Oegema et al. (1) raise thoughtful comments about our article (2). We… Expand
2017
2017
In this work, we have investigated in mammalian cells how microtubule nucleation at centrosome and Golgi apparatus are… Expand
Highly Cited
2016
Highly Cited
2016
Meitinger et al. perform a genome-wide CRISPR/Cas9 screen for centrinone resistance and identify a 53BP1-USP28 module as critical… Expand
2016
2016
Significance During mammalian cell division, the contiguous Golgi ribbon is first vesiculated and then partitioned into the… Expand
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Highly Cited
2015
Highly Cited
2015
Giving an old organelle the old heave-ho Centrioles are ancient cellular organelles that build centrosomes, the major microtubule… Expand