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cemadotin

Known as: N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-prolinebenzylamide 
A synthetic dolastatin 15 analogue with potential antineoplastic activity. Cemadotin suppresses spindle microtubule dynamics by binding to tubulin… Expand
National Institutes of Health

Papers overview

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2020
2020
Pretubulysin is a bio-precursor of highly toxic tetrapeptide tubulysins. Although pretubulysin has a much simpler chemical… Expand
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2014
2014
Antibody–drug conjugates are increasingly being used for cancer therapy, but little is known about their ability to promote… Expand
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2014
2014
Chemotherapeutic resistance due to over expression of Inhibitor of Apoptosis Proteins (IAPs) XIAP, survivin and livin has been… Expand
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2014
2014
Antibody–drug conjugates are increasingly being used for cancer therapy, but little is known about their ability to promote… Expand
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2013
2013
Antibody-drug conjugates (ADCs) are promising agents for the selective delivery of cytotoxic drugs to specific cells (for example… Expand
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2009
2009
Tasidotin, an oncolytic drug in phase II clinical trials, is a peptide analog of the antimitotic depsipeptide dolastatin 15. In… Expand
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2005
2005
The targeting of microtubules is an important mechanism for cancer chemotherapy. However, there is still a need for improved… Expand
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2003
2003
The antimitotic depsipeptide dolastatin 15 was radiolabeled with tritium in its amino-terminal dolavaline residue. Dolastatin 15… Expand
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2000
2000
Purpose: The dolastatins are a class of naturally occurring cytotoxic peptides which function by inhibiting microtubule assembly… Expand
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1998
1998
Cemadotin (LU103793) (NSC D-669356) is a water-soluble synthetic analogue of dolastatin 15 that inhibits cell proliferation in… Expand
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