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LU 103793

Known as: LU-103793, LU103793 
 
National Institutes of Health

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2 relations

Broader (2)

cemadotincemadotin hydrochloride

Papers overview

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Review
2012
Review
2012
A review of pharmacological and toxicological potentials of marine cyanobacterial metabolites.
Novel toxic metabolites from marine cyanobacteria have been thoroughly explored. Biologically active and chemically diverse… Expand
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2001
2001
Activity of the dolastatin analogue, LU103793, in malignant melanoma.
LU103793, a synthetic analogue of dolastatin 15, showed interesting pre-clinical activity in melanoma xenografts. In this phase… Expand
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1999
1999
Synthesis and cytostatic properties of structure-simplified analogs of dolastatin 15.
The linear peptide dolastatin 15 (1), a potent antineoplastic constituent from the shell-less mollusk Dolabella auricularia, has… Expand
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1998
1998
Phase I and pharmacokinetic study of the water-soluble dolastatin 15 analog LU103793 in patients with advanced solid malignancies.
PURPOSE To determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLTs), and pharmacokinetic profile of the… Expand
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1998
1998
Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action.
Cemadotin (LU103793) (NSC D-669356) is a water-soluble synthetic analogue of dolastatin 15 that inhibits cell proliferation in… Expand
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1996
1996
Phase I Clinical and Pharmacokinetic Study of LU103793 (Cemadotin Hydrochloride) as an Intravenous Bolus Injection in Patients with Metastatic Solid Tumors
Background: To study the toxicity and pharmacokinetics of LU103793 (Cematodin®), a novel cytotoxic anticancer drug being an… Expand
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1995
1995
LU103793 (NSC D-669356): a synthetic peptide that interacts with microtubules and inhibits mitosis.
LU103793 (NSC D-669356) is a new synthetic derivative of Dolastatin 15, an antiproliferative compound which was isolated from the… Expand
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