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LU 103793

Known as: LU-103793, LU103793 
National Institutes of Health

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2 relations

Broader (2)

cemadotincemadotin hydrochloride

Papers overview

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Review
2012
Review
2012
A review of pharmacological and toxicological potentials of marine cyanobacterial metabolites
Novel toxic metabolites from marine cyanobacteria have been thoroughly explored. Biologically active and chemically diverse… 
2001
2001
Activity of the dolastatin analogue, LU103793, in malignant melanoma.
LU103793, a synthetic analogue of dolastatin 15, showed interesting pre-clinical activity in melanoma xenografts. In this phase… 
1999
1999
Synthesis and cytostatic properties of structure-simplified analogs of dolastatin 15.
  • M. HuW. S. Huang
  • The journal of peptide research : official…
  • 1999
  • Corpus ID: 30141325
The linear peptide dolastatin 15 (1), a potent antineoplastic constituent from the shell-less mollusk Dolabella auricularia, has… 
1998
1998
Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action.
Cemadotin (LU103793) (NSC D-669356) is a water-soluble synthetic analogue of dolastatin 15 that inhibits cell proliferation in… 
1998
1998
Phase I and pharmacokinetic study of the water-soluble dolastatin 15 analog LU103793 in patients with advanced solid malignancies.
PURPOSE To determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLTs), and pharmacokinetic profile of the… 
1996
1996
Phase I Clinical and Pharmacokinetic Study of LU103793 (Cemadotin Hydrochloride) as an Intravenous Bolus Injection in Patients with Metastatic Solid Tumors
Background: To study the toxicity and pharmacokinetics of LU103793 (Cematodin®), a novel cytotoxic anticancer drug being an… 
Highly Cited
1995
Highly Cited
1995
LU103793 (NSC D-669356): a synthetic peptide that interacts with microtubules and inhibits mitosis.
LU103793 (NSC D-669356) is a new synthetic derivative of Dolastatin 15, an antiproliferative compound which was isolated from the… 
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