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ceftezole

Known as: (6R,7R)-8-Oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-3-((1,3,4-thiadiazol-2-ylthio)methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Ceftezol, demethylcefazolin 
A semisynthetic first-generation cephalosporin with antibacterial activity. Ceftezole binds to and inactivates penicillin-binding proteins (PBPs… Expand
National Institutes of Health

Related topics

Related topics

6 relations

Broader (2)

Anti-Bacterial AgentsCefazolin

Narrower (3)

CeloslinFalomesinceftezole sodium
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
A gold immunochromatographic assay for the rapid and simultaneous detection of fifteen β-lactams.
A novel gold immunochromatographic assay (GICA) based on anti-β-lactam receptors was innovatively developed that successfully… Expand
2013
2013
Validation of the cephalosporin intradermal skin test for predicting immediate hypersensitivity: a prospective study with drug challenge
Cephalosporin is a major offending agent in terms of drug hypersensitivity along with penicillin. Cephalosporin intradermal skin… Expand
2007
2007
Ceftezole, a cephem antibiotic, is an α-glucosidase inhibitor with in vivo anti-diabetic activity
Using a high throughput-compatible assay to screen for potential alpha-glucosidase inhibitors, we found that the beta-lactam… Expand
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Highly Cited
1995
Highly Cited
1995
Relationship between structure and convulsant properties of some beta-lactam antibiotics following intracerebroventricular microinjection in rats.
The epileptogenic activities of several beta-lactam antibiotics were compared following their intracerebroventricular… Expand
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1989
1989
Epileptogenic activity of some β-lactam derivatives: Structure-activity relationship
The epileptogenic activity of several derivatives of beta-lactam was compared following their intracerebroventricular… Expand
1988
1988
Mechanism of action of cephalosporins and resistance caused by decreased affinity for penicillin-binding proteins in Bacteroides fragilis.
The susceptibilities of 52 clinical isolates of Bacteroides fragilis to five monoanionic cephalosporins were examined… Expand
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1983
1983
Epileptogenic Activity of Cephalosporins in Rats and Their Structure‐Activity Relationship
Summary: The epileptogenic properties of 10 cephalosporins and penicillin G were compared by intraventricular application to rats… Expand
Review
1980
Review
1980
Medicinal chemistry of tetrazoles.
Publisher Summary Tetrazole itself exhibits no pharmacological activity; however, many of its derivatives possess interesting… Expand
1976
1976
In Vitro and In Vivo Evaluation of Ceftezole, a New Cephalosporin Derivative
Ceftezole, a new cephalosporin derivative, was compared with cefazolin, cephaloridine, and cephalothin. Data obtained indicate… Expand
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1976
1976
Ceftezole, a new cephalosporin C derivative I. In vitro and in vivo antimicrobial activity.
Ceftezole, a new cephalosporin antibiotic similar to cefazolin, has the following chemical structure: (6R,7R)-8-oxo-7[2-(1H… Expand
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