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catechol O-methyltransferase activity

Known as: S-COMT (soluble form of catechol-O-methyltransferase), COMT II, catechol methyltransferase activity 
Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. [EC:2.1.1.6]
National Institutes of Health

Papers overview

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2011
2011
BACKGROUND The catechol-O-methyltransferase enzyme plays a key role in the function of prefrontal cortex, accounting for most of… Expand
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2011
2011
A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has… Expand
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2010
2010
Catechol-O-methyl transferase (COMT) is an important estrogen-metabolizing enzyme, and common genetic variants in this gene could… Expand
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Highly Cited
2009
Highly Cited
2009
BackgroundIn the development of borderline personality disorder (BPD) both genetic and environmental factors have important roles… Expand
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2006
2006
In recent years, it has been proposed that synaptic dysfunction may be an important etiological factor for Alzheimer's disease… Expand
2004
2004
The tobacco gene encoding caffeic acid-O-methyltransferase of class II (COMT II) was isolated, including a 1.7 kb 5′-flanking… Expand
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2001
2001
High nonphysiological doses of l-dopa are administered to Parkinson's disease (PD) patients, to replenish the depleted dopamine… Expand
2000
2000
Caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase (COMT, EC 1.2.1.68) catalyzes at least two reactions in lignin… Expand
Highly Cited
1999
Highly Cited
1999
The biosynthesis of lignin monomers involves two methylation steps catalyzed by orthodiphenol-O-methyltransferases: caffeic acid… Expand
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1979
1979
Catechol-O-methyltransferase (COMT: EC 2.1.1.6) has been shown to exist in the soluble fraction of rat liver as two distinct… Expand