Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

catechol O-methyltransferase activity

Known as: S-COMT (soluble form of catechol-O-methyltransferase), COMT II, catechol methyltransferase activity 
Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. [EC:2.1.1.6]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Catechol-O-Methyltransferase Valine158Methionine Polymorphism Moderates Methylphenidate Effects on Oppositional Symptoms in Boys with Attention-Deficit/Hyperactivity Disorder
BACKGROUND The catechol-O-methyltransferase enzyme plays a key role in the function of prefrontal cortex, accounting for most of… Expand
  • table 1
  • figure 1
  • figure 2
2011
2011
Association study of a functional catechol-o-methyltransferase polymorphism and cognitive function in patients with dementia.
A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has… Expand
  • table 1
  • table 2
  • table 3
2010
2010
Association of COMT haplotypes and breast cancer risk in caucasian women.
Catechol-O-methyl transferase (COMT) is an important estrogen-metabolizing enzyme, and common genetic variants in this gene could… Expand
  • table I
  • table II
Highly Cited
2009
Highly Cited
2009
Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients
BackgroundIn the development of borderline personality disorder (BPD) both genetic and environmental factors have important roles… Expand
  • table 1
  • table 2
  • table 3
  • table 4
2006
2006
Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia
In recent years, it has been proposed that synaptic dysfunction may be an important etiological factor for Alzheimer's disease… Expand
2004
2004
Structure of the tobacco caffeic acid O-methyltransferase (COMT) II gene: identification of promoter sequences involved in gene inducibility by various stimuli
The tobacco gene encoding caffeic acid-O-methyltransferase of class II (COMT II) was isolated, including a 1.7 kb 5′-flanking… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
2001
2001
l-Dopa Upregulates the Expression and Activities of Methionine Adenosyl Transferase and Catechol-O-Methyltransferase
High nonphysiological doses of l-dopa are administered to Parkinson's disease (PD) patients, to replenish the depleted dopamine… Expand
2000
2000
Substrate preferences of caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferases in developing stems of alfalfa (Medicago sativa L.).
Caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase (COMT, EC 1.2.1.68) catalyzes at least two reactions in lignin… Expand
Highly Cited
1999
Highly Cited
1999
Tobacco O-methyltransferases involved in phenylpropanoid metabolism. The different caffeoyl-coenzyme A/5-hydroxyferuloyl-coenzyme A 3/5-O-methyltransferase and caffeic acid/5-hydroxyferulic acid 3/5…
The biosynthesis of lignin monomers involves two methylation steps catalyzed by orthodiphenol-O-methyltransferases: caffeic acid… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
1979
1979
Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization.
Catechol-O-methyltransferase (COMT: EC 2.1.1.6) has been shown to exist in the soluble fraction of rat liver as two distinct… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE