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castanospermine

Known as: 1,6,7,8-tetrahydroxyoctahydroindolizine, castinospermine 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (3)

1-epicastanospermine6,7-diepicastanospermine6-epicastanospermine

Broader (8)

AlkaloidsAnti-HIV AgentsAnti-Inflammatory Agents, Non-SteroidalAntiviral Agents

Papers overview

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Highly Cited
2012
Highly Cited
2012
Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial.
Highly Cited
1998
Highly Cited
1998
Inhibition of Glucose Trimming with Castanospermine Reduces Calnexin Association and Promotes Proteasome Degradation of the α-Subunit of the Nicotinic Acetylcholine Receptor*
To identify factors involved in the expression of ligand-gated ion channels, we expressed nicotinic acetylcholine receptors in… 
Highly Cited
1995
Highly Cited
1995
The α-Glucosidase I Inhibitor Castanospermine Alters Endothelial Cell Glycosylation, Prevents Angiogenesis, and Inhibits Tumor Growth
Abstract The development of drugs that target the tumor neovasculature may hold promise in inhibiting tumor growth. Experiments… 
Highly Cited
1995
Highly Cited
1995
The Lesions of Locoweed (Astragalus mollissimus), Swainsonine, and Castanospermine in Rats
To better characterize and compare the toxicity of and lesions produced by locoweed (Astragalus mollissimus) with those of… 
Highly Cited
1990
Highly Cited
1990
Demonstration that Golgi endo-alpha-D-mannosidase provides a glucosidase-independent pathway for the formation of complex N-linked oligosaccharides of glycoproteins.
Highly Cited
1988
Highly Cited
1988
Inhibition of v-fms-induced tumor growth in nude mice by castanospermine.
Castanospermine, an indolizidine alkaloid isolated from the seeds of the chestnut tree Castanospermum australe, has been shown to… 
Highly Cited
1986
Highly Cited
1986
Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids.
Highly Cited
1985
Highly Cited
1985
Castanospermine inhibits alpha-glucosidase activities and alters glycogen distribution in animals.
Castanospermine, an inhibitor of alpha-glucosidase activity, was injected into rats to determine its effects in vivo. Daily… 
Highly Cited
1985
Highly Cited
1985
Castanospermine inhibits glucosidase I and glycoprotein secretion in human hepatoma cells.
We studied the effect of the plant alkaloid castanospermine on the biosynthesis and secretion of human hepatoma glycoproteins… 
Highly Cited
1983
Highly Cited
1983
Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin.
Castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that inhibits alpha- and beta-glucosidase in… 
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