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carboxyprimaquine

National Institutes of Health

Papers overview

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2005
2005
The pharmacokinetics of primaquine in calves after subcutaneous and intravenous administration
The pharmacokinetics of primaquine was studied in calves of 180–300 kg live weight. Primaquine was injected at 0.29 mg/kg (0.51… 
2004
2004
Enantioselective analysis of primaquine and its metabolite carboxyprimaquine by capillary electrophoresis
An enantioselective capillary electrophoresis method for the simultaneous determination of primaquine (PQ) and carboxyprimaquine… 
2004
2004
Effect of Aliphatic Side-Chain Substituents on the Antimalarial Activity and on the Metabolism of Primaquine Studied Using Mitochondria and Microsome Preparations
The substitution of two deuterium atoms on the α-carbon of the primaquine side chain was found to produce a sevenfold decrease in… 
1999
1999
Dipeptide Derivatives of Primaquine as Transmission-Blocking Antimalarials: Effect of Aliphatic Side-Chain Acylation on the Gametocytocidal Activity and on the Formation of Carboxyprimaquine in Rat…
AbstractPurpose. Dipeptide derivatives of primaquine (PQ) with reduced oxidative deamination to the inactive metabolite… 
1996
1996
High-performance liquid chromatographic determination of primaquine and carboxyprimaquine concentrations in plasma and blood cells in Plasmodium vivax malaria cases following chronic dosage with…
1994
1994
Simultaneous determination of primaquine and carboxyprimaquine in plasma using high-performance liquid chromatography with electrochemical detection.
1992
1992
Rat liver microsomal and mitochondrial metabolism of primaquine in vitro.
The profiles of major metabolites of primaquine (PQ) produced from liver microsomal (MC) and mitochondrial (MT) metabolism were… 
1991
1991
The conversion of primaquine into primaquine-aldehyde, primaquine-alcohol, and carboxyprimaquine, a major plasma metabolite.
Although efficacy and toxicity of primaquine (PQ) depend on bioconversion, the process is poorly understood, even for… 
1989
1989
Development of a magnetisable solid-phase fluoroimmunoassay for primaquine and carboxyprimaquine.
Primaquine coupled to keyhole limpet hemocyanin was used as an immunogen to produce antiprimaquine antibodies in three sheep. The… 
1987
1987
Biotransformation of primaquine in vitro with human K562 and bone marrow cells.
Although the antimalarial activity, hemolytic and methemoglobinemic side effects, and detoxification of primaquine are all… 
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