candesartan cilexetil

Known as: candesartan cilexitil, 1H-Benzimidazolium, 7-carboxy-1-(2-((cyclohexylcarbonyl)oxy)ethyl)-2-ethoxy-1-(2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)-, hydroxide, inner salt, (+-)-, 1-(cyclohexylocarbonyloxy)ethyl-2-ethoxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)-1H-benzimidazole-7-carboxylate 
A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. After hydrolysis of candesartan… (More)

Topic mentions per year

Topic mentions per year

1994-2018
020406019942018

Papers overview

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2011
2011
Candesartan cilexetil (CC), an inactive prodrug of candesartan, was rapidly hydrolyzed into active candesartan during absorption… (More)
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2009
2009
Sparingly, water-soluble drugs such as candesartan cilexetil offer challenges in developing a drug product with adequate… (More)
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2006
2006
The angiotensin II receptor blockers irbesartan and losartan effectively reduce blood pressure and proteinuria in childhood. We… (More)
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2004
2004
BACKGROUND Signalling of angiotensin II via angiotensin II type 1 receptor (AT1) promotes cardiac and renal fibrosis, but its… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND AND PURPOSE The Acute Candesartan Cilexetil Therapy in Stroke Survivors (ACCESS) study was designed to assess the… (More)
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1999
1999
Renal autoregulatory efficiency is compromised in angiotensin-II (AngII)-dependent Goldblatt hypertension. The current studies… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Chronic heart failure (CHF) is an increasing burden to health care. Pharmacological treatment with angiotensin… (More)
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1998
1998
The objectives of this double-blind, multicenter, randomized, parallel-arm, placebo-controlled study were to evaluate the dose… (More)
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1997
1997
Candesartan is a new generation angiotensin II type 1 receptor blocker, characterised by tight binding to and slow dissociation… (More)
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1997
1997
The effects of chronic treatment with an angiotensin II receptor antagonist, candesartan cilexetil (TCV-116, 0.1, 1, 10 mg/kg… (More)
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