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candesartan cilexetil

Known as: candesartan cilexitil, 1H-Benzimidazolium, 7-carboxy-1-(2-((cyclohexylcarbonyl)oxy)ethyl)-2-ethoxy-1-(2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)-, hydroxide, inner salt, (+-)-, 1-(cyclohexylocarbonyloxy)ethyl-2-ethoxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)-1H-benzimidazole-7-carboxylate 
A synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. After hydrolysis of candesartan… 
National Institutes of Health

Related topics

Related topics

25 relations

Narrower (6)

AmiasAtacandBlopressKenzen
Angiotensin 2 Receptor Antagonists [MoA]Angiotensin 2 Type 1 Receptor Antagonists [MoA]Congestive heart failureDecreased Blood Pressure [PE]

Broader (5)

Angiotensin II Type 1 Receptor BlockersAntihypertensive AgentsBenzimidazolesBiphenyl Compounds

Papers overview

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Highly Cited
2016
Highly Cited
2016
Candesartan cilexetil loaded solid lipid nanoparticles for oral delivery: characterization, pharmacokinetic and pharmacodynamic evaluation
Abstract Candesartan cilexetil (CC) is used in the treatment of hypertension and heart failure. It has poor aqueous solubility… 
Highly Cited
2004
Highly Cited
2004
Angiotensin AT2 receptor contributes to cardiovascular remodelling of aged rats during chronic AT1 receptor blockade.
Highly Cited
2000
Highly Cited
2000
Angiotensin II type 1 receptor antagonist decreases plasma levels of tumor necrosis factor alpha, interleukin-6 and soluble adhesion molecules in patients with chronic heart failure.
Highly Cited
1999
Highly Cited
1999
Improvement in exercise tolerance and symptoms of congestive heart failure during treatment with candesartan cilexetil. Symptom, Tolerability, Response to Exercise Trial of Candesartan Cilexetil in…
BACKGROUND The renin-angiotensin system plays an important part in the pathogenesis of congestive heart failure (CHF). This study… 
Highly Cited
1998
Highly Cited
1998
The antihypertensive effect and tolerability of candesartan cilexetil, a new generation angiotensin II antagonist, in comparison with losartan.
This multicentre study compared the antihypertensive effect and tolerability of the novel angiotensin II antagonist candesartan… 
Highly Cited
1997
Highly Cited
1997
Pharmacokinetics of candesartan after single and repeated doses of candesartan cilexetil in young and elderly healthy volunteers.
Candesartan cilexetil is rapidly and completely hydrolysed to the active compound candesartan during absorption from the… 
Highly Cited
1997
Highly Cited
1997
Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats.
The effects of chronic treatment with an angiotensin II receptor antagonist, candesartan cilexetil (TCV-116, 0.1, 1, 10 mg/kg… 
Highly Cited
1997
Highly Cited
1997
Candesartan cilexetil, a new generation angiotensin II antagonist, provides dose dependent antihypertensive effect.
Candesartan is a new generation angiotensin II type 1 receptor blocker, characterised by tight binding to and slow dissociation… 
Review
1997
Review
1997
Candesartan cilexetil: a review of its preclinical pharmacology.
Candesartan is a highly potent, long-acting and selective angiotensin II type 1 (AT1) receptor blocker. It is administered orally… 
Highly Cited
1993
Highly Cited
1993
Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974…
The angiotensin II (AII) antagonistic action of 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1H-benzi mid azole-7… 
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