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Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial
TLDR
Intensive lowering of blood pressure in patients with hypertension was associated with a low rate of cardiovascular events and the potential benefit of a low dose of acetylsalicylic acid in the treatment of hypertension was assessed. Expand
The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial
TLDR
In elderly hypertensive patients, a slightly more effective blood pressure reduction during candesartan-based therapy, compared with control therapy, was associated with a modest, statistically non-significant, reduction in major cardiovascular events and with a marked reduction in non-fatal stroke. Expand
EFFECT ON MORTALITY OF METOPROLOL IN ACUTE MYOCARDIAL INFARCTION A Double-blind Randomised Trial
TLDR
The effect of metoprolol on mortality was compared with that of placebo in a double blind randomised trial in patients with definite or suspected acute myocardial infarction and there was a reduction of 36% (p less than 0.03). Expand
Beta-blockers versus diuretics in hypertensive men: main results from the HAPPHY trial.
TLDR
Antihypertensive treatment based on a beta-blocker or on a thiazide diuretic could not be shown to affect the prevention of hypertensive complications, including CHD, to a different extent. Expand
Stroke prevention with the angiotensin II type 1-receptor blocker candesartan in elderly patients with isolated systolic hypertension: the Study on Cognition and Prognosis in the Elderly (SCOPE).
TLDR
In elderly patients with ISH, antihypertensive treatment based on the ARB candesartan resulted in a significant 42% RR reduction in stroke in comparison with other antihyertensive treatment, despite little difference in blood pressure reduction. Expand
Findings and implications of the Study on COgnition and Prognosis in the Elderly (SCOPE) – A review
TLDR
It is strongly suggested that candesartan treatment reduces cardiovascular morbidity and mortality in old and very old patients with mild to moderate hypertension and may also have positive effects on cognitive function and quality of life. Expand
Primary prevention with metoprolol in patients with hypertension. Mortality results from the MAPHY study.
TLDR
Total mortality was significantly lower for metoprolol than for thiazide diuretics because of fewer deaths from coronary heart disease and stroke and the benefit demonstrated in patients treated with metoprole seems to have important implications for clinical practice. Expand
Coffee consumption and coronary heart disease in middle-aged Swedish men.
TLDR
With the aid of non-parametric multivariate analysis of the combined population sample and the series of MI patients, a significant association was found between coffee consumption and MI. Expand
Candesartan cilexetil: safety and tolerability in healthy volunteers and patients with hypertension.
TLDR
Canesartan cilexetil possesses an excellent tolerability profile that extends to a wide variety of patients including the elderly and it does not aggravate co-existing risk factors such as hyperlipidaemia or glucose intolerance. Expand
The Study on COgnition and Prognosis in the Elderly (SCOPE) – Major CV events and stroke in subgroups of patients
TLDR
This analysis indicates consistent favourable effects of candesartan‐based therapy on major cardiovascular events and stroke across the different subgroups of patients, however, the benefit was particularly pronounced in patients who entered the study with a previous stroke. Expand
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